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Title: Chelating platform for delivery of radionuclides

Abstract

Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1892574
Patent Number(s):
11235076
Application Number:
16/329,178
Assignee:
Fred Hutchinson Cancer Research Center (Seattle, WA); The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
A1094419; AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 08/28/2017
Country of Publication:
United States
Language:
English

Citation Formats

Strong, Roland K., Rupert, Peter, Abergel, Rebecca J., Captain, Ilya, and Deblonde, Gauthier J. P. Chelating platform for delivery of radionuclides. United States: N. p., 2022. Web.
Strong, Roland K., Rupert, Peter, Abergel, Rebecca J., Captain, Ilya, & Deblonde, Gauthier J. P. Chelating platform for delivery of radionuclides. United States.
Strong, Roland K., Rupert, Peter, Abergel, Rebecca J., Captain, Ilya, and Deblonde, Gauthier J. P. Tue . "Chelating platform for delivery of radionuclides". United States. https://www.osti.gov/servlets/purl/1892574.
@article{osti_1892574,
title = {Chelating platform for delivery of radionuclides},
author = {Strong, Roland K. and Rupert, Peter and Abergel, Rebecca J. and Captain, Ilya and Deblonde, Gauthier J. P.},
abstractNote = {Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {2}
}

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