Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides
Abstract
Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States); Isis Innovation Ltd., Oxford (United Kingdom)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1892573
- Patent Number(s):
- 11235055
- Application Number:
- 16/023,871
- Assignee:
- Triad National Security, LLC (Los Alamos, NM); Isis Innovation Limited (Felton, GB)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC52-06NA25396; AI100645
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 06/29/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Korber, Bette T. M., Hanke, Tomas, and McMichael, Andrew. Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides. United States: N. p., 2022.
Web.
Korber, Bette T. M., Hanke, Tomas, & McMichael, Andrew. Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides. United States.
Korber, Bette T. M., Hanke, Tomas, and McMichael, Andrew. Tue .
"Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides". United States. https://www.osti.gov/servlets/purl/1892573.
@article{osti_1892573,
title = {Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides},
author = {Korber, Bette T. M. and Hanke, Tomas and McMichael, Andrew},
abstractNote = {Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {2}
}
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