Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Makriyannis, Alexandros; Shukla, Vidyanand G.; Alapafuja, Shakiru O.

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Title: Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Abstract

Disclosed are compounds of general formulas I-III that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL.

Inventors:: Makriyannis, Alexandros; Shukla, Vidyanand G.; Alapafuja, Shakiru O.

Issue Date:: 2022-01-04

Research Org.:: Northeastern Univ., Boston, MA (United States)

Sponsoring Org.:: USDOE; National Institutes of Health (NIH)

OSTI Identifier:: 1892504

Patent Number(s):: 11214578

Application Number:: 16/745,325

Assignee:: Northwestern University (Boston, MA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D205/04 - having no double bonds between ring members or between ring members and non-ring members
C07D211/16 - with acylated ring nitrogen atom
C07D211/46 - having a hydrogen atom as the second substituent in position 4
C07D211/54 - Sulfur atoms
C07D213/64 - attached in position 2 or 6
C07D213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C07D213/75 - Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
C07D213/84 - Nitriles
C07D213/85 - in position 3
C07D215/04 - with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
C07D215/12 - with substituted hydrocarbon radicals attached to ring carbon atoms
C07D233/61 - with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
C07D241/04 - having no double bonds between ring members or between ring members and non-ring members
C07D257/04 - Five-membered rings
C07D295/14 - substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D295/195 - Radicals derived from nitrogen analogues of carboxylic acids
C07D295/26 - Sulfur atoms
C07D401/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D401/12 - linked by a chain containing hetero atoms as chain links
C07D401/14 - containing three or more hetero rings
C07D403/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D403/14 - containing three or more hetero rings
C07D405/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D411/12 - linked by a chain containing hetero atoms as chain links
C07D471/08 - Bridged systems
C07D487/08 - Bridged systems
C07D491/107 - with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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DOE Contract Number:: DA007215; FG02-00ER45852

Resource Type:: Patent

Resource Relation:: Patent File Date: 01/16/2020

Country of Publication:: United States

Language:: English

Citation Formats


                    Makriyannis, Alexandros, Shukla, Vidyanand G., and Alapafuja, Shakiru O. Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof.  United States: N. p., 2022. 
        Web.

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                    Makriyannis, Alexandros, Shukla, Vidyanand G., & Alapafuja, Shakiru O. Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof.  United States.

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                    Makriyannis, Alexandros, Shukla, Vidyanand G., and Alapafuja, Shakiru O. Tue .  
        "Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof".  United States.  https://www.osti.gov/servlets/purl/1892504.

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@article{osti_1892504,

  title        = {Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof},

  author       = {Makriyannis, Alexandros and Shukla, Vidyanand G. and Alapafuja, Shakiru O.},

  abstractNote = {Disclosed are compounds of general formulas I-III that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2022},

  month        = {1}

}

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Works referenced in this record:

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Substituted Phenols as Active Agents Inhibiting VEGF Production
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Monoacylglcerol Lipase Inhibitors for Modulation of Cannabinoid Activity
patent-application, February 2011

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Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof
patent, February 2020

Makriyannis, Alexandros; Shukla, Vidyanand G.; Alapafuja, Shakiru O.
US Patent Document 10,570,146
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/10570146

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Title: Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Abstract

Citation Formats

Arylthio piperidinamide of (4-quinolinylamino)benzoic acid and S-oxidized derivatives patent, April 1988

Substituted Phenols as Active Agents Inhibiting VEGF Production patent-application, October 2008

Heteroaryl Substituted Urea Modulators of Fatty Acid Amide Hydrolase patent-application, March 2014

Chlorine Generator patent-application, January 2009

Substituted triazole derivatives as oxytocin antagonists patent, July 2009

Azetidine derivatives as FAAH inhibitors patent, May 2013

Fatty Acid Amide Hydrolase Inhibitors from Virtual Screening of the Endocannabinoid System journal, June 2006

Azetidine Ring Compounds and Drugs Comprising the Same patent-application, June 2007

Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome patent-application, June 2013

Heteroaryl-Substituted Urea Modulators of Fatty Acid Amide Hydrolase patent-application, March 2009

Monoacylglcerol Lipase Inhibitors for Modulation of Cannabinoid Activity patent-application, February 2011

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides patent, November 1991

Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof patent, February 2020

Arylthio piperidinamide of (4-quinolinylamino)benzoic acid and S-oxidized derivatives
patent, April 1988

Substituted Phenols as Active Agents Inhibiting VEGF Production
patent-application, October 2008

Heteroaryl Substituted Urea Modulators of Fatty Acid Amide Hydrolase
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Chlorine Generator
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Substituted triazole derivatives as oxytocin antagonists
patent, July 2009

Azetidine derivatives as FAAH inhibitors
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Fatty Acid Amide Hydrolase Inhibitors from Virtual Screening of the Endocannabinoid System
journal, June 2006

Azetidine Ring Compounds and Drugs Comprising the Same
patent-application, June 2007

Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
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Heteroaryl-Substituted Urea Modulators of Fatty Acid Amide Hydrolase
patent-application, March 2009

Monoacylglcerol Lipase Inhibitors for Modulation of Cannabinoid Activity
patent-application, February 2011

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
patent, November 1991

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