Method for protection against genotoxic mutagenesis
Abstract
A method and pharmaceutical for protecting against genotoxic damage in irradiated cells are disclosed. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides. 10 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Chicago, IL (United States)
- OSTI Identifier:
- 187071
- Patent Number(s):
- 5488042
- Application Number:
- PAN: 7-851,210; TRN: 96:006434
- Assignee:
- Arch Development Corp., Chicago, IL (United States)
- DOE Contract Number:
- W-31109-ENG-38
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 30 Jan 1996
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; RADIOPROTECTIVE SUBSTANCES; CHEMICAL PREPARATION; GENE MUTATIONS; RADIOINDUCTION; GENETIC RADIATION EFFECTS; ANIMAL CELLS; TRANSFERASES
Citation Formats
Grdina, D J. Method for protection against genotoxic mutagenesis. United States: N. p., 1996.
Web.
Grdina, D J. Method for protection against genotoxic mutagenesis. United States.
Grdina, D J. Tue .
"Method for protection against genotoxic mutagenesis". United States.
@article{osti_187071,
title = {Method for protection against genotoxic mutagenesis},
author = {Grdina, D J},
abstractNote = {A method and pharmaceutical for protecting against genotoxic damage in irradiated cells are disclosed. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides. 10 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}
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