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Title: Method for protection against genotoxic mutagenesis

A method and pharmaceutical for protecting against genotoxic damage in irradiated cells are disclosed. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides. 10 figs.
Inventors:
Issue Date:
OSTI Identifier:
187071
Assignee:
Arch Development Corp., Chicago, IL (United States) PTO; SCA: 560120; PA: EDB-96:040731; SN: 96001532303
Patent Number(s):
US 5,488,042/A/
Application Number:
PAN: 7-851,210; TRN: 96:006434
Contract Number:
W-31109-ENG-38
Resource Relation:
Other Information: PBD: 30 Jan 1996
Research Org:
Univ. of Chicago, IL (United States)
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; RADIOPROTECTIVE SUBSTANCES; CHEMICAL PREPARATION; GENE MUTATIONS; RADIOINDUCTION; GENETIC RADIATION EFFECTS; ANIMAL CELLS; TRANSFERASES