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Title: Method for protection against genotoxic mutagenesis

Abstract

A method and pharmaceutical for protecting against genotoxic damage in irradiated cells are disclosed. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides. 10 figs.

Inventors:
Issue Date:
Research Org.:
Univ. of Chicago, IL (United States)
OSTI Identifier:
187071
Patent Number(s):
5,488,042
Application Number:
PAN: 7-851,210; TRN: 96:006434
Assignee:
Arch Development Corp., Chicago, IL (United States)
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 30 Jan 1996
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; RADIOPROTECTIVE SUBSTANCES; CHEMICAL PREPARATION; GENE MUTATIONS; RADIOINDUCTION; GENETIC RADIATION EFFECTS; ANIMAL CELLS; TRANSFERASES

Citation Formats

Grdina, D J. Method for protection against genotoxic mutagenesis. United States: N. p., 1996. Web.
Grdina, D J. Method for protection against genotoxic mutagenesis. United States.
Grdina, D J. Tue . "Method for protection against genotoxic mutagenesis". United States.
@article{osti_187071,
title = {Method for protection against genotoxic mutagenesis},
author = {Grdina, D J},
abstractNote = {A method and pharmaceutical for protecting against genotoxic damage in irradiated cells are disclosed. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides. 10 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}