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Title: MOMP telonanoparticles, and related compositions, methods and systems


A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a Chlamydia major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.

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Issue Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
OSTI Identifier:
Patent Number(s):
Application Number:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
DOE Contract Number:  
Resource Type:
Resource Relation:
Patent File Date: 05/01/2018
Country of Publication:
United States

Citation Formats

Coleman, Matthew A., Fischer, Nicholas O., Rasley, Amy, Blanchette, Craig D., and Peterson, Todd. MOMP telonanoparticles, and related compositions, methods and systems. United States: N. p., 2021. Web.
Coleman, Matthew A., Fischer, Nicholas O., Rasley, Amy, Blanchette, Craig D., & Peterson, Todd. MOMP telonanoparticles, and related compositions, methods and systems. United States.
Coleman, Matthew A., Fischer, Nicholas O., Rasley, Amy, Blanchette, Craig D., and Peterson, Todd. Tue . "MOMP telonanoparticles, and related compositions, methods and systems". United States.
title = {MOMP telonanoparticles, and related compositions, methods and systems},
author = {Coleman, Matthew A. and Fischer, Nicholas O. and Rasley, Amy and Blanchette, Craig D. and Peterson, Todd},
abstractNote = {A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a Chlamydia major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {12}

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Computer programs to identify and classify amphipathic alpha helical domains.
journal, February 1992

Apolipoprotein nanodiscs with telodendrimer
patent, May 2017

Apolipoprotein Nanodiscs with Telodendrimer
patent-application, March 2018

Cytochromes P450 in Nanodiscs
journal, January 2011

Structure, phase transitions and polymerizability of multilayers of some diacetylene monocarboxylic acids
journal, May 1980

Cell-free synthesis of a functional G protein-coupled receptor complexed with nanometer scale bilayer discs
journal, January 2011

HoxE—a subunit specific for the pentameric bidirectional hydrogenase complex (HoxEFUYH) of cyanobacteria
journal, April 2002

MOMP from Campylobacter jejuni Is a Trimer of 18-Stranded β-Barrel Monomers with a Ca 2+ Ion Bound at the Constriction Zone
journal, November 2016

Insertion of Membrane Proteins into Discoidal Membranes Using a Cell-Free Protein Expression Approach
journal, August 2008

Disassembly of Nanodiscs with Cholate
journal, June 2007

In Vitro Protein Synthesis Systems For Membrane Proteins That Include Adolipoproteins And Phospholipid-Adolipoprotein Particles
patent-application, May 2007

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
journal, April 2007

Charge‐reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses
journal, September 2001

  • Bacher, Gerold; Szymanski, Wladyslaw W.; Kaufman, Stanley L.
  • Journal of Mass Spectrometry, Vol. 36, Issue 9, p. 1038-1052

RNA Stable Isotope Probing, a Novel Means of Linking Microbial Community Function to Phylogeny
journal, November 2002

Protein Prenyltransferases
journal, March 1996

Apolipoprotein A-I mimetic peptide helix number and helix linker influence potentially anti-atherogenic properties
journal, March 2008

Apolipoprotein A-I mimics
patent, July 2016

Disentangling the perturbational effects of amino acid substitutions in the DNA-binding domain of p53
journal, February 1999

Human Recombinant Apolipoprotein E-Enriched Liposomes Can Mimic Low-Density Lipoproteins as Carriers for the Site-Specific Delivery of Antitumor Agents
journal, September 1997

Nanobiotechnology applications of reconstituted high density lipoprotein
journal, January 2010

Some Observations on the Type I and Type II Microsomal Binding Spectra
journal, January 1971

Immobilization of His-Tagged Proteins on Nickel-Chelating Nanolipoprotein Particles
journal, March 2009

EMAN2: An extensible image processing suite for electron microscopy
journal, January 2007

Synthesis of many different types of organic small molecules using one automated process
journal, March 2015

Thermotolerant Hydrogenases: Biological Diversity, Properties, and Biotechnological Applications
journal, January 2008

Nanolipoprotein Particles And Related Methods And Systems For Protein Capture, Solubilization, And/Or Purification
patent-application, July 2009

Phospholipid polymers—Synthesis and spectral characteristics
journal, October 1980

Polymerization of diacetylenes in multilayers
journal, June 1979

Characterization and Purification of Polydisperse Reconstituted Lipoproteins and Nanolipoprotein Particles
journal, July 2009

Phospholipid phase transitions in homogeneous nanometer scale bilayer discs
journal, December 2003

Minimum Amino Acid Residues of an α-Helical Peptide Leading to Lipid Nanodisc Formation
journal, January 2014

Nanodiscs Allow Phage Display Selection for Ligands to Non-Linear Epitopes on Membrane Proteins
journal, September 2013

Solubilisation of methane monooxygenase from Methylococcus capsulatus (Bath)
journal, July 1989

Membrane-Mimetic Films of Asymmetric Phosphatidylcholine Lipid Bolaamphiphiles
journal, January 2006

Enzyme immobilization for use in biofuel cells and sensors
patent-application, May 2004

Stability of pressure-extruded liposomes made from archaeobacterial ether lipids
journal, November 1994

Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol.
journal, October 1994

Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis
journal, October 2013

Helical and tubular microstructures formed by polymerizable phosphatidylcholines
journal, September 1987

Application on Monoolein as a New Helper Lipid in Transfection
patent-application, July 2011

Effect of Chain Length and Unsaturation on Elasticity of Lipid Bilayers
journal, July 2000

Structural Basis for Thermal Stability of Human Low-Density Lipoprotein
journal, March 2005

Hydrogen Production under Aerobic Conditions by Membrane-Bound Hydrogenases from Ralstonia Species
journal, August 2008

Nanodisks: hydrophobic drug delivery vehicles
journal, March 2008

Lipidated Glycosaminoglycan Particles for the Delivery of Nucleic Acids
patent-application, May 2015

Assembly of anthrax toxin pore: Lethal-factor complexes into lipid nanodiscs: Assembly of Anthrax Toxin Pore: Lethal Factor Complexes
journal, February 2013

Synthetic Apolipoproteins, and Related Compositions Methods and Systems for Nanolipoprotein Particles Formation
patent-application, July 2018

Synthesis of Native Proteins by Chemical Ligation
journal, June 2000

In Vitro Reconstitution of Assembly of Apolipoprotein B48-containing Lipoproteins
journal, March 1997

Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes.
journal, June 1988

Reconstitution and Imaging of a Membrane Protein in a Nanometer-Size Phospholipid Bilayer
journal, September 1998

Photocatalytic Hydrogen Production And Polypeptides Capable Of Same
patent-application, August 2010

Preparation and Characterization of Reconstituted Lipid–Synthetic Polymer Discoidal Particles
journal, November 2015

Immunoproteomic Discovery of Novel T Cell Antigens from the Obligate Intracellular Pathogen Chlamydia
journal, February 2008

The Fluid Mosaic Model of the Structure of Cell Membranes
journal, February 1972

Generation of immunoliposomes using recombinant single-chain Fv fragments bound to Ni-NTA-liposomes
journal, August 2005

A Novel Apolipoprotein C-II Mimetic Peptide That Activates Lipoprotein Lipase and Decreases Serum Triglycerides in Apolipoprotein E–Knockout Mice
journal, November 2014

Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake
journal, August 2016

The micromorphology and protein characterization of rubber particles in Ficus carica, Ficus benghalensis and Hevea brasiliensis
journal, March 2003

Nanolipoprotein Particles Comprising Hydrogenases and Related Products, Methods and Systems
patent-application, July 2009

Attaching histidine-tagged peptides and proteins to lipid-based carriers through use of metal-ion-chelating lipids
journal, December 2002

PmpG 303-311 , a Protective Vaccine Epitope That Elicits Persistent Cellular Immune Responses in Chlamydia muridarum-Immune Mice
journal, June 2012

Isolation of Monodisperse Nanodisc-Reconstituted Membrane Proteins Using Free Flow Electrophoresis
journal, March 2013

Systems for orthogonal self-assembly of electroactive monolayers on Au and ITO: an approach to molecular electronics
journal, July 1995

Microfluidic Biofuel Cell
patent-application, December 2007

Method for forming proteoliposome and method for forming giant proteoliposome
patent, December 1994

Lysine-Based Polymeric Linkers
patent-application, August 2009

Modulation of human erg K+ channel gating by activation of a G protein-coupled receptor and protein kinase C
journal, September 1998

The growing impact of click chemistry on drug discovery
journal, December 2003

Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine.
journal, August 1985

Identification and cellular localization of human PFTAIRE1
journal, April 2001

Atomic Force Microscope Studies of the Fusion of Floating Lipid Bilayers
journal, June 2007

Membrane scaffold proteins
patent, May 2006

Fluorescence Correlation Spectroscopy: Past, Present, Future
journal, December 2011

Functional Cell-free Synthesis of a Seven Helix Membrane Protein: In situ Insertion of Bacteriorhodopsin into Liposomes
journal, August 2007

Phase Separation of Lipid Microdomains Controlled by Polymerized Lipid Bilayer Matrices
journal, December 2009

Enzyme-Catalyzed O 2 Removal System for Electrochemical Analysis under Ambient Air: Application in an Amperometric Nitrate Biosensor
journal, February 2012

High level cell-free expression and specific labeling of integral membrane proteins
journal, February 2004

A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer
journal, October 2009

Molecular cloning of a gene encoding the histamine H2 receptor.
journal, January 1991

Thermotropic Phase Transition in Soluble Nanoscale Lipid Bilayers
journal, August 2005

Membrane scaffold proteins and embedded membrane proteins
patent, February 2010

A high-throughput shotgun mutagenesis approach to mapping B-cell antibody epitopes
journal, July 2014

Functional reconstitution of β 2 -adrenergic receptors utilizing self-assembling Nanodisc technology
journal, May 2006

Antimicrobial Activities of Amine- and Guanidine-Functionalized Cholic Acid Derivatives
journal, June 1999

Drug Delivery Systems: Entering the Mainstream
journal, March 2004

Apolipoprotein Nanodiscs with Telodendrimer
patent-application, June 2013

Assembly of single bacteriorhodopsin trimers in bilayer nanodiscs
journal, June 2006

Shape behavior of lipid vesicles as the basis of some cellular processes
journal, October 2002

The Biosynthesis of Natural Rubber
journal, June 1990

In-depth analysis of the membrane and cytosolic proteome of red blood cells
journal, August 2006