Oxygen-responsive bacterial gene switch
Abstract
The invention provided herein relates to sequence determinants that elicit certain levels of gene expression and methods for obtaining engineered ligand-responsive gene switches comprising these sequence determinants. More particularly, the invention provided herein relates to molecular building blocks (i.e., discrete nucleotide sequences), synthetic ligand-responsive gene switches comprising an assembly of these molecular building blocks, and methods of using synthetic ligand-responsive gene switches as customizable and controllable expression systems and sensors.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1860180
- Patent Number(s):
- 11203759
- Application Number:
- 15/698,302
- Assignee:
- WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, WI)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FC02-07ER64494; FG02-04ER25627; GM045844
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 09/07/2017
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Kiley, Patricia J., and Park, Dan Mcfarland. Oxygen-responsive bacterial gene switch. United States: N. p., 2021.
Web.
Kiley, Patricia J., & Park, Dan Mcfarland. Oxygen-responsive bacterial gene switch. United States.
Kiley, Patricia J., and Park, Dan Mcfarland. Tue .
"Oxygen-responsive bacterial gene switch". United States. https://www.osti.gov/servlets/purl/1860180.
@article{osti_1860180,
title = {Oxygen-responsive bacterial gene switch},
author = {Kiley, Patricia J. and Park, Dan Mcfarland},
abstractNote = {The invention provided herein relates to sequence determinants that elicit certain levels of gene expression and methods for obtaining engineered ligand-responsive gene switches comprising these sequence determinants. More particularly, the invention provided herein relates to molecular building blocks (i.e., discrete nucleotide sequences), synthetic ligand-responsive gene switches comprising an assembly of these molecular building blocks, and methods of using synthetic ligand-responsive gene switches as customizable and controllable expression systems and sensors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {12}
}
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