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Title: Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics

Abstract

Provided are implantable, injectable and/or surface mounted biomedical devices and related methods for interfacing with a target tissue. The devices have a substrate, one or more microfluidic channels embedded in or supported by the substrate and a fluid actuator in operational communication with one or more reservoirs and responsive to a wireless control signal. The components of the device are specially configured and packaged to be ultra-thin and mechanically compliant. In some embodiments, the devices are self-powered and fully implantable. The devices can be shaped to provide injection in a minimally invasive manner, thereby avoiding unnecessary tissue damage and providing a platform for long-term implantation for interfacing with biological tissue.

Inventors:
; ; ;
Issue Date:
Research Org.:
Univ. of Illinois at Urbana-Champaign, IL (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1860014
Patent Number(s):
11160489
Application Number:
15/738,043
Assignee:
The Board of Trustees of the University of Illinois (Urbana, IL)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
DOE Contract Number:  
F31 MH101956; FG02-07ER46453; FG02-07ER46471; R01DA037152; R01NS081707
Resource Type:
Patent
Resource Relation:
Patent File Date: 07/01/2016
Country of Publication:
United States
Language:
English

Citation Formats

Rogers, John A., Bruchas, Michael Raymond, Jeong, Jaewoong, and McCall, Jordan Gary. Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics. United States: N. p., 2021. Web.
Rogers, John A., Bruchas, Michael Raymond, Jeong, Jaewoong, & McCall, Jordan Gary. Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics. United States.
Rogers, John A., Bruchas, Michael Raymond, Jeong, Jaewoong, and McCall, Jordan Gary. Tue . "Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics". United States. https://www.osti.gov/servlets/purl/1860014.
@article{osti_1860014,
title = {Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics},
author = {Rogers, John A. and Bruchas, Michael Raymond and Jeong, Jaewoong and McCall, Jordan Gary},
abstractNote = {Provided are implantable, injectable and/or surface mounted biomedical devices and related methods for interfacing with a target tissue. The devices have a substrate, one or more microfluidic channels embedded in or supported by the substrate and a fluid actuator in operational communication with one or more reservoirs and responsive to a wireless control signal. The components of the device are specially configured and packaged to be ultra-thin and mechanically compliant. In some embodiments, the devices are self-powered and fully implantable. The devices can be shaped to provide injection in a minimally invasive manner, thereby avoiding unnecessary tissue damage and providing a platform for long-term implantation for interfacing with biological tissue.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {11}
}

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Ultrasensitive DNA sequence detection using nanoscale ZnO sensor arrays
journal, May 2006


Biodegradable Metals for Cardiovascular Stent Application: Interests and New Opportunities
journal, June 2011


Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces
journal, November 2012


Microfabricated injectable drug delivery system
patent, September 2002


Hydrolysis of Mg–salt and MgH2–salt mixtures prepared by ball milling for hydrogen production
journal, June 2006


Soft, Wearable Microfluidic Systems Capable of Capture, Storage, and Sensing of Biofluids
patent-application, March 2018


SCH 23390—The first selective dopamine D-1 antagonist
journal, July 1983


Stability of high-dose morphine chloride injection upon heat sterilization: comparison of UV-spectroscopy and HPLC
journal, April 1996


Optogenetic investigation of neural circuits underlying brain disease in animal models
journal, March 2012


Transfer Printing Techniques for Materials Assembly and Micro/Nanodevice Fabrication
journal, August 2012


State-Dependent Calcium Signaling in Dendritic Spines of Striatal Medium Spiny Neurons
journal, October 2004


Process for producing patterned optical filter layers on substrates
patent, April 2010


Locus Coeruleus Kappa-Opioid Receptors Modulate Reinstatement of Cocaine Place Preference Through a Noradrenergic Mechanism
journal, June 2013


Solubility of nano-zinc oxide in environmentally and biologically important matrices
journal, December 2011

  • Reed, Robert B.; Ladner, David A.; Higgins, Christopher P.
  • Environmental Toxicology and Chemistry, Vol. 31, Issue 1, p. 93-99
  • https://doi.org/10.1002/etc.708

Devices and methods for pattern generation by ink lithography
patent-application, March 2008


Methods and devices for fabricating three-dimensional nanoscale structures
patent, April 2010


Printable semiconductor structures and related methods of making and assembling
patent, September 2010


Molecular and Cellular Approaches for Diversifying and Extending Optogenetics
journal, April 2010


Optogenetics in Neural Systems
journal, July 2011


Medical implant systems
patent-application, December 2004