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Title: Direct determination of antibody chain pairing

Abstract

Methods are described for using a combination of mass spectroscopic and proteomic approaches for identifying the specific pairing of heavy and light chains for an intact antibody, an antibody fragment, a mixture of intact antibodies, or a mixture of antibody fragments.

Inventors:
Issue Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1859978
Patent Number(s):
11152198
Application Number:
16/782,705
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
AC06-76RL01830; R43GM122131-01; R44GM122131-02
Resource Type:
Patent
Resource Relation:
Patent File Date: 02/05/2020
Country of Publication:
United States
Language:
English

Citation Formats

Shaw, Jared B. Direct determination of antibody chain pairing. United States: N. p., 2021. Web.
Shaw, Jared B. Direct determination of antibody chain pairing. United States.
Shaw, Jared B. Tue . "Direct determination of antibody chain pairing". United States. https://www.osti.gov/servlets/purl/1859978.
@article{osti_1859978,
title = {Direct determination of antibody chain pairing},
author = {Shaw, Jared B.},
abstractNote = {Methods are described for using a combination of mass spectroscopic and proteomic approaches for identifying the specific pairing of heavy and light chains for an intact antibody, an antibody fragment, a mixture of intact antibodies, or a mixture of antibody fragments.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {10}
}

Works referenced in this record:

Mass Spectrometer
patent-application, December 2008


Polyvalent metal ion-containing antibody combining site catalysts
patent, August 1993


Novel human genes and methods of use thereof
patent-application, July 2003