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Title: Modified bacterial microcompartment shell proteins

Abstract

The present invention provides for a fusion protein comprising (1) a bacterial microcompartment (BMC) shell protein comprising one or more subunit, and (2) a first component of a specific-binding pair, operably linked to the BMC shell protein such that the first component faces (i) a lumen (inside) side, or (ii) outside of a BMC shell formed incorporating the fusion protein and the fusion protein does not disrupt or prevent the folding of the BMC shell protein or the ability of the BMC shell protein to integrate with other BMC shell proteins into a BMC shell; wherein the first component is capable of forming a stable or irreversible interaction with a second component of the specific-binding pair.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
University of California, Berkeley, CA (United States); Michigan State Univ., East Lansing, MI (Unites States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1840488
Patent Number(s):
11130788
Application Number:
16/412,133
Assignee:
The Regents of the University of California (Oakland, CA); Board of Trustees of Michigan State University (East Lansing, MI)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
1R01AI114975-01; AC02-05CH11231; FG02-91ER20021
Resource Type:
Patent
Resource Relation:
Patent File Date: 05/14/2019
Country of Publication:
United States
Language:
English

Citation Formats

Hagen, Andrew R., Kerfeld, Cheryl A., Sloan, Nancy B., Sutter, Markus, and Ferlez, Bryan H. Modified bacterial microcompartment shell proteins. United States: N. p., 2021. Web.
Hagen, Andrew R., Kerfeld, Cheryl A., Sloan, Nancy B., Sutter, Markus, & Ferlez, Bryan H. Modified bacterial microcompartment shell proteins. United States.
Hagen, Andrew R., Kerfeld, Cheryl A., Sloan, Nancy B., Sutter, Markus, and Ferlez, Bryan H. Tue . "Modified bacterial microcompartment shell proteins". United States. https://www.osti.gov/servlets/purl/1840488.
@article{osti_1840488,
title = {Modified bacterial microcompartment shell proteins},
author = {Hagen, Andrew R. and Kerfeld, Cheryl A. and Sloan, Nancy B. and Sutter, Markus and Ferlez, Bryan H.},
abstractNote = {The present invention provides for a fusion protein comprising (1) a bacterial microcompartment (BMC) shell protein comprising one or more subunit, and (2) a first component of a specific-binding pair, operably linked to the BMC shell protein such that the first component faces (i) a lumen (inside) side, or (ii) outside of a BMC shell formed incorporating the fusion protein and the fusion protein does not disrupt or prevent the folding of the BMC shell protein or the ability of the BMC shell protein to integrate with other BMC shell proteins into a BMC shell; wherein the first component is capable of forming a stable or irreversible interaction with a second component of the specific-binding pair.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {9}
}

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