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Title: Hydrophobically modified polypeptoids and uses thereof

Abstract

A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types of repeat units, where one or more of the repeat units have nitrogen atom having a hydrophobic substituent attached thereto. Methods of making the hydrophobically modified polypeptoids are also provided, as well as uses of the hydrophobically modified polypeptoids, for example in liposomal drug delivery.

Inventors:
; ; ;
Issue Date:
Research Org.:
Louisiana State Univ., Baton Rouge, LA (United States); Tulane Univ., New Orleans, LA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1840460
Patent Number(s):
11123433
Application Number:
16/306,429
Assignee:
Board of Supervisors of Louisiana State University (Baton Rouge, LA); The Administrators of the Tulane Educational Fund (New Orleans, LA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
SC0012432
Resource Type:
Patent
Resource Relation:
Patent File Date: 02/07/2017
Country of Publication:
United States
Language:
English

Citation Formats

Zhang, Donghui, John, Vijay T., Zhang, Yuehang, and Xuan, Sunting. Hydrophobically modified polypeptoids and uses thereof. United States: N. p., 2021. Web.
Zhang, Donghui, John, Vijay T., Zhang, Yuehang, & Xuan, Sunting. Hydrophobically modified polypeptoids and uses thereof. United States.
Zhang, Donghui, John, Vijay T., Zhang, Yuehang, and Xuan, Sunting. Tue . "Hydrophobically modified polypeptoids and uses thereof". United States. https://www.osti.gov/servlets/purl/1840460.
@article{osti_1840460,
title = {Hydrophobically modified polypeptoids and uses thereof},
author = {Zhang, Donghui and John, Vijay T. and Zhang, Yuehang and Xuan, Sunting},
abstractNote = {A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types of repeat units, where one or more of the repeat units have nitrogen atom having a hydrophobic substituent attached thereto. Methods of making the hydrophobically modified polypeptoids are also provided, as well as uses of the hydrophobically modified polypeptoids, for example in liposomal drug delivery.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {9}
}

Works referenced in this record:

Use of Amphiphilic Biocompatible Polymers for Solubilization of Hydrophobic Drugs
patent-application, February 2010


Structure/Function Analysis of Peptoid/Lipitoid:DNA Complexes
journal, September 2003


Alkylated SP-C Peptoid Compounds and Related Surfactant Compositions
patent-application, May 2013


Cell Transfecting Formulations of Small Interfering RNA, Related Compositions and Methods of Making and Use
patent-application, January 2015


Synthesis and characterization of thermo-responsive polypeptoid bottlebrushes
journal, January 2014


Thermoresponsive Poly(α-peptoid)s: Tuning the Cloud Point Temperatures by Composition and Architecture
journal, April 2012


Drug delivery systems: Advanced technologies potentially applicable in personalized treatments
journal, March 2010


Surface-Immobilized Antimicrobial Peptoids
patent-application, February 2010


Crystallization and Melting Behaviors of Cyclic and Linear Polypeptoids with Alkyl Side Chains
journal, October 2013


Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization
journal, June 2012


Novel biomimetic peptoid polymers
patent-application, February 2012