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Title: PET imaging of zinc transport

Abstract

A method for producing a solution including a positron emitting zinc cation of 63Zn, and the method comprises bombarding a solution target including 63Cu with high energy protons to produce a solution including a positron emitting zinc cation. A method for detecting or ruling out Alzheimer's disease in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to β-amyloid in the patient, and acquiring an image to detect the presence or absence of β-amyloid in the patient. A method for detecting or ruling out cancer in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to tissue in the patient; and acquiring an image using a medical imaging technique to detect zinc distribution in tissue in the patient.

Inventors:
; ; ;
Issue Date:
Research Org.:
Mayo Foundation for Medical Education and Research, Rochester, MN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1840381
Patent Number(s):
11103602
Application Number:
16/355,335
Assignee:
Mayo Foundation for Medical Education and Research (Rochester, MN)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
DOE Contract Number:  
SC0008947
Resource Type:
Patent
Resource Relation:
Patent File Date: 03/15/2019
Country of Publication:
United States
Language:
English

Citation Formats

DeGrado, Timothy R., Pandey, Mukesh K., Engelbrecht, Hendrik Petrus, and Lowe, Val J. PET imaging of zinc transport. United States: N. p., 2021. Web.
DeGrado, Timothy R., Pandey, Mukesh K., Engelbrecht, Hendrik Petrus, & Lowe, Val J. PET imaging of zinc transport. United States.
DeGrado, Timothy R., Pandey, Mukesh K., Engelbrecht, Hendrik Petrus, and Lowe, Val J. Tue . "PET imaging of zinc transport". United States. https://www.osti.gov/servlets/purl/1840381.
@article{osti_1840381,
title = {PET imaging of zinc transport},
author = {DeGrado, Timothy R. and Pandey, Mukesh K. and Engelbrecht, Hendrik Petrus and Lowe, Val J.},
abstractNote = {A method for producing a solution including a positron emitting zinc cation of 63Zn, and the method comprises bombarding a solution target including 63Cu with high energy protons to produce a solution including a positron emitting zinc cation. A method for detecting or ruling out Alzheimer's disease in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to β-amyloid in the patient, and acquiring an image to detect the presence or absence of β-amyloid in the patient. A method for detecting or ruling out cancer in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to tissue in the patient; and acquiring an image using a medical imaging technique to detect zinc distribution in tissue in the patient.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {8}
}

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