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Title: Transgenic silkworms expressing spider silk

Abstract

Transgenic silkworms stably expressing synthetic spider silk genes or composite silkworm/spider silk genes are disclosed. The exogenous spider silk genes are stably intergrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic spider silk proteins and composite spider silk-silkworm genes and proteins are provided. The expression of exogenous spider silk genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/spider silk fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.

Inventors:
; ; ;
Issue Date:
Research Org.:
Utah State Univ., Logan, UT (United States)
Sponsoring Org.:
USDOE; National Science Foundation (NSF)
OSTI Identifier:
1840348
Patent Number(s):
11089767
Application Number:
15/942,185
Assignee:
Utah State University (Logan, UT)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
EE0006857; IIP1318194
Resource Type:
Patent
Resource Relation:
Patent File Date: 03/30/2018
Country of Publication:
United States
Language:
English

Citation Formats

Lewis, Randolph V., Xia, Lijin, Zhang, Xiaoli, and Jones, Justin A. Transgenic silkworms expressing spider silk. United States: N. p., 2021. Web.
Lewis, Randolph V., Xia, Lijin, Zhang, Xiaoli, & Jones, Justin A. Transgenic silkworms expressing spider silk. United States.
Lewis, Randolph V., Xia, Lijin, Zhang, Xiaoli, and Jones, Justin A. Tue . "Transgenic silkworms expressing spider silk". United States. https://www.osti.gov/servlets/purl/1840348.
@article{osti_1840348,
title = {Transgenic silkworms expressing spider silk},
author = {Lewis, Randolph V. and Xia, Lijin and Zhang, Xiaoli and Jones, Justin A.},
abstractNote = {Transgenic silkworms stably expressing synthetic spider silk genes or composite silkworm/spider silk genes are disclosed. The exogenous spider silk genes are stably intergrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic spider silk proteins and composite spider silk-silkworm genes and proteins are provided. The expression of exogenous spider silk genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/spider silk fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {8}
}

Works referenced in this record:

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