DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Therapeutic phages and methods thereof

Abstract

The present invention relates, in part, to engineered viruses (e.g., engineered phages), phage cocktails, and methods of producing and/or identifying viruses for targeting pathogenic bacteria.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1840275
Patent Number(s):
11066691
Application Number:
16/570,197
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
NA0003525
Resource Type:
Patent
Resource Relation:
Patent File Date: 09/13/2019
Country of Publication:
United States
Language:
English

Citation Formats

Williams, Kelly Porter, Branda, Steven, and Krishnakumar, Raga. Therapeutic phages and methods thereof. United States: N. p., 2021. Web.
Williams, Kelly Porter, Branda, Steven, & Krishnakumar, Raga. Therapeutic phages and methods thereof. United States.
Williams, Kelly Porter, Branda, Steven, and Krishnakumar, Raga. Tue . "Therapeutic phages and methods thereof". United States. https://www.osti.gov/servlets/purl/1840275.
@article{osti_1840275,
title = {Therapeutic phages and methods thereof},
author = {Williams, Kelly Porter and Branda, Steven and Krishnakumar, Raga},
abstractNote = {The present invention relates, in part, to engineered viruses (e.g., engineered phages), phage cocktails, and methods of producing and/or identifying viruses for targeting pathogenic bacteria.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {7}
}

Works referenced in this record:

Archaeal viruses and bacteriophages: comparisons and contrasts
journal, June 2014


Engineering Modular Viral Scaffolds for Targeted Bacterial Population Editing
journal, September 2015


A fully decompressed synthetic bacteriophage øX174 genome assembled and archived in yeast
journal, December 2012


Characterisation of Host Growth after Infection with a Broad-Range Freshwater Cyanopodophage
journal, January 2014


The Multiplication of Bacteriophage in vivo and its Protective Effect Against an Experimental Infection with Shigella Dysenteriae
journal, September 1943


Bacteriophages isolated from Lake Michigan demonstrate broad host-range across several bacterial phyla
journal, October 2015


Phages of Staphylococcus aureus and their impact on host evolution
journal, January 2014


Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction
journal, June 2012


Bacteriophage for Biocontrol of Foodborne Pathogens: Calculations and Considerations
journal, January 2010


Protocells for Plasmid and RNP Delivery in the Treatment of Cancer and Other Disease States
patent-application, February 2018


Chemical synthesis of the mouse mitochondrial genome
journal, October 2010


A century of the phage: past, present and future
journal, November 2015


Re-establishing a place for phage therapy in western medicine
journal, May 2015


Simultaneous amplification of multiple targets
patent, June 1995


Genome Replication, Synthesis, and Assembly of the Bacteriophage T7 in a Single Cell-Free Reaction
journal, July 2012


Cross-genus rebooting of custom-made, synthetic bacteriophage genomes in L-form bacteria
journal, January 2018


Multiplexed microfluidic approach for nucleic acid enrichment
patent, April 2016


PHASTER: a better, faster version of the PHAST phage search tool
journal, May 2016


Escherichia coli-based cell-free synthesis of virus-like particles
journal, January 2008


Staphylococcemia 1931–1940. Five Hundred Patients
journal, June 1942


Molecular epidemiology and genomics of group A Streptococcus
journal, July 2015


A new antibiotic kills pathogens without detectable resistance
journal, January 2015


A Method for Generation Phage Cocktail with Great Therapeutic Potential
journal, March 2012


Rebooting of synthetic bacteriophage genome in L-form bacteria
patent-application, March 2020


Recombineering in Mycobacterium tuberculosis
journal, December 2006


Genetically modified bacteriophages
journal, January 2016


Genetic and Phenotypic Characterization of a Pseudomonas aeruginosa Population with High Frequency of Genomic Islands
journal, May 2012


Interstrain transfer of the large pathogenicity island (PAPI-1) of Pseudomonas aeruginosa
journal, December 2006


An Unusual Phage Repressor Encoded by Mycobacteriophage BPs
journal, September 2015


Contemporary Phage Biology: From Classic Models to New Insights
journal, March 2018


PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates.
journal, March 1994


Bacteriophage Therapy
journal, December 1934


The Increase of Bacteriophage in Vivo During Experimental Infections with Shigella paradysenteriae , Flexner, in Mice
journal, March 1945


Detection of mycobacteria by multiplex nucleic acid amplification
patent, November 1995


General concepts for PCR primer design.
journal, December 1993


BRED: A Simple and Powerful Tool for Constructing Mutant and Recombinant Bacteriophage Genomes
journal, December 2008


Mash: fast genome and metagenome distance estimation using MinHash
journal, June 2016


Experimental single-strain mobilomics reveals events that shape pathogen emergence
journal, July 2016


The Epidemiology of Burn Wound Infections: Then and Now
journal, August 2003


Switches in Bacteriophage Lambda Development
journal, December 2005


Islander: a database of precisely mapped genomic islands in tRNA and tmRNA genes
journal, November 2014


Phage Therapy in Clinical Practice: Treatment of Human Infections
journal, January 2010


DNA signatures for detecting genetic engineering in bacteria
journal, January 2008


New candidates for regulated gene integrity revealed through precise mapping of integrative genetic elements
journal, March 2020


Genomic islands ofPseudomonas aeruginosa
journal, January 2009


Enzymatic assembly of DNA molecules up to several hundred kilobases
journal, April 2009


Traffic at the tmRNA Gene
journal, February 2003


Evaporation management in digital microfluidic devices
patent-application, June 2018


Phage treatment of human infections
journal, March 2011


Resistance Determinants and Mobile Genetic Elements of an NDM-1-Encoding Klebsiella pneumoniae Strain
journal, June 2014


Construction of a Super-Competent Bacillus subtilis 168 Using the PmtlA-comKS Inducible Cassette
journal, December 2015


PhagePhisher: a pipeline for the discovery of covert viral sequences in complex genomic datasets
journal, March 2016


Carriers for Plasmid and RNP Delivery in the Treatment of Cancer and Other Disease States
patent-application, February 2018


Genetically Engineered Phages: a Review of Advances over the Last Decade
journal, June 2016