Synthetic transcription factor and uses thereof
Abstract
The present invention provides for a synthetic transcription factor (TF) comprising a first peptide capable of binding a target ligand, a second peptide capable of binding a target DNA, and a peptide linker linking the first and second peptides. The present invention also provide for a system for modulating the mutagenesis frequency of a host cell. The host cell has a mutator rate (R) which is inversely proportional to a phenotypic trait (P).
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1824016
- Patent Number(s):
- 11021525
- Application Number:
- 14/735,985
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 06/10/2015
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Chou, Howard H., Keasling, Jay D., and Zotchev, Sergey. Synthetic transcription factor and uses thereof. United States: N. p., 2021.
Web.
Chou, Howard H., Keasling, Jay D., & Zotchev, Sergey. Synthetic transcription factor and uses thereof. United States.
Chou, Howard H., Keasling, Jay D., and Zotchev, Sergey. Tue .
"Synthetic transcription factor and uses thereof". United States. https://www.osti.gov/servlets/purl/1824016.
@article{osti_1824016,
title = {Synthetic transcription factor and uses thereof},
author = {Chou, Howard H. and Keasling, Jay D. and Zotchev, Sergey},
abstractNote = {The present invention provides for a synthetic transcription factor (TF) comprising a first peptide capable of binding a target ligand, a second peptide capable of binding a target DNA, and a peptide linker linking the first and second peptides. The present invention also provide for a system for modulating the mutagenesis frequency of a host cell. The host cell has a mutator rate (R) which is inversely proportional to a phenotypic trait (P).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {6}
}
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