Synthetic transcription factor and uses thereof
Abstract
The present invention provides for a synthetic transcription factor (TF) comprising a first peptide capable of binding a target ligand, a second peptide capable of binding a target DNA, and a peptide linker linking the first and second peptides. The present invention also provide for a system for modulating the mutagenesis frequency of a host cell. The host cell has a mutator rate (R) which is inversely proportional to a phenotypic trait (P).
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1824016
- Patent Number(s):
- 11021525
- Application Number:
- 14/735,985
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 06/10/2015
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Chou, Howard H., Keasling, Jay D., and Zotchev, Sergey. Synthetic transcription factor and uses thereof. United States: N. p., 2021.
Web.
Chou, Howard H., Keasling, Jay D., & Zotchev, Sergey. Synthetic transcription factor and uses thereof. United States.
Chou, Howard H., Keasling, Jay D., and Zotchev, Sergey. Tue .
"Synthetic transcription factor and uses thereof". United States. https://www.osti.gov/servlets/purl/1824016.
@article{osti_1824016,
title = {Synthetic transcription factor and uses thereof},
author = {Chou, Howard H. and Keasling, Jay D. and Zotchev, Sergey},
abstractNote = {The present invention provides for a synthetic transcription factor (TF) comprising a first peptide capable of binding a target ligand, a second peptide capable of binding a target DNA, and a peptide linker linking the first and second peptides. The present invention also provide for a system for modulating the mutagenesis frequency of a host cell. The host cell has a mutator rate (R) which is inversely proportional to a phenotypic trait (P).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 01 00:00:00 EDT 2021},
month = {Tue Jun 01 00:00:00 EDT 2021}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Directed evolution of microorganisms
patent, April 2002
- Schellenberger, Volker; Liu, Amy D.; Selifonova, Olga V.
- US Patent Document 6,365,410
Directed evolution of microorganisms
patent-application, May 2004
- Schellengerger, Volker; Liu, Amy D.; Selifonova, Olga V.
- US Patent Application 10/719571; 20040086972
Engineered stimulus-responsive switches
patent-application, March 2003
- Schwartz, John Jacob; Jacobson, Joseph; Das Gupta, Ruchira
- US Patent Application 10/032827; 20030049799
Inducible Expression System Transcription Modulators Comprising A Distributed Protein Transduction Domain And Methods For Using The Same
patent-application, May 2012
- Bisgrove, Dwayne; Sagawa, Hiroaki
- US Patent Application 13/303652; 20120129254
Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
patent, November 1995
- Gossen, Manfred; Bujard, Hermann
- US Patent Document 5,464,758
Directed evolution of microorganisms
patent-application, September 2008
- Schellenberger, Volker; Liu, Amy D.; Selifonova, Olga V.
- US Patent Application 11/584112; 20080220502
Method of Directing the Evolution of an Organism
patent-application, December 2009
- Ogawa, Masanori; Horiuchi, Takayuki; Tabata, Kazufumi
- US Patent Application 12/327663; 20090311790