Title: Methods for identifying interactions amongst microorganisms

Abstract

Disclosed herein are methods, compositions, and systems for determining specific microbial taxa, within a complex consortia of mixed taxa, which are interacting with each other in an environment of interest. In some embodiments, after diluting a sample comprising multiple different taxa of microorganisms, dilutions of the sample are cultivated for determining taxonomic information and interactions of multiple taxa of microorganisms in the sample.

Inventors:

Justice, Nicholas B.; Arkin, Adam P.

Issue Date:

Tue May 25 00:00:00 EDT 2021

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE; National Institutes of Health (NIH)

OSTI Identifier:

1823987

Patent Number(s):

11015154

Application Number:

15/807,498

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12C - BEER

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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C - CHEMISTRY C12 - BIOCHEMISTRY C12C - BEER

C12C1/02 - Pretreatment of grains, e.g. washing, steeping

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/02 - involving viable microorganisms
C12Q1/025 - {for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
C12Q1/689 - for bacteria
C12Q2600/158 - Expression markers

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16B - BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY

G16B40/00 - ICT specially adapted for biostatistics
G16B40/20 - Supervised data analysis

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DOE Contract Number:  

1F32GM113547-01; AC02-05CH11231

Resource Type:

Patent

Resource Relation:

Patent File Date: 11/08/2017

Country of Publication:

United States

Language:

English