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Title: Acid-degradable and bioerodible modified polyhydroxylated materials

Abstract

Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby the hydroxyl groups are modified by an acid-catalyzed reaction between a polydroxylated polymer and a reagent such as acetals, aldehydes, vinyl ethers and ketones such that the modified polyhydroxylated polymers become insoluble in water but freely soluble in common organic solvents allowing for the facile preparation of acid-sensitive materials. Materials made from these polymers can be made to degrade in a pH-dependent manner. Both hydrophobic and hydrophilic cargoes were successfully loaded into particles made from the present polymers using single and double emulsion techniques, respectively. Due to its ease of preparation, processability, pH-sensitivity, and biocompatibility, of the present modified polyhydroxylated polymers should find use in numerous drug delivery applications.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1823920
Patent Number(s):
10995156
Application Number:
15/474,827
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
DOE Contract Number:  
AC02-05CH11231; RO1 EB005824; RO1GM44885-16
Resource Type:
Patent
Resource Relation:
Patent File Date: 03/30/2017
Country of Publication:
United States
Language:
English

Citation Formats

Frechet, Jean M. J., Bachelder, Eric M., Beaudette, Tristan T., and Broaders, Kyle E. Acid-degradable and bioerodible modified polyhydroxylated materials. United States: N. p., 2021. Web.
Frechet, Jean M. J., Bachelder, Eric M., Beaudette, Tristan T., & Broaders, Kyle E. Acid-degradable and bioerodible modified polyhydroxylated materials. United States.
Frechet, Jean M. J., Bachelder, Eric M., Beaudette, Tristan T., and Broaders, Kyle E. Tue . "Acid-degradable and bioerodible modified polyhydroxylated materials". United States. https://www.osti.gov/servlets/purl/1823920.
@article{osti_1823920,
title = {Acid-degradable and bioerodible modified polyhydroxylated materials},
author = {Frechet, Jean M. J. and Bachelder, Eric M. and Beaudette, Tristan T. and Broaders, Kyle E.},
abstractNote = {Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby the hydroxyl groups are modified by an acid-catalyzed reaction between a polydroxylated polymer and a reagent such as acetals, aldehydes, vinyl ethers and ketones such that the modified polyhydroxylated polymers become insoluble in water but freely soluble in common organic solvents allowing for the facile preparation of acid-sensitive materials. Materials made from these polymers can be made to degrade in a pH-dependent manner. Both hydrophobic and hydrophilic cargoes were successfully loaded into particles made from the present polymers using single and double emulsion techniques, respectively. Due to its ease of preparation, processability, pH-sensitivity, and biocompatibility, of the present modified polyhydroxylated polymers should find use in numerous drug delivery applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {5}
}

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