Modular assemblies and systems for cell cultures and methods thereof

Hatch, Anson; Abhyankar, Vinay; Koh, Chung-Yan

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Title: Modular assemblies and systems for cell cultures and methods thereof

Abstract

The present invention relates to modular assemblies and systems for conducting cell analyses. In particular embodiments, an assembly has micron-scale fluidic structures, thereby minimizing sample use, and possesses a modular architecture that facilitates disassembly of the apparatus. Thus, one such modular assembly facilitates on-chip cell growth and on-chip assays; and then, as needed, the assembly can be disassembled to provide direct access to the cells that were incubated and treated within the chip. Methods of making and using such assemblies, as well as systems thereof, are further described herein.

Inventors:: Hatch, Anson; Abhyankar, Vinay; Koh, Chung-Yan

Issue Date:: 2021-04-27

Research Org.:: Sandia National Lab. (SNL-CA), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1823893

Patent Number(s):: 10988723

Application Number:: 15/273,408

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY

Show more

C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
C12M23/16 - {Microfluidic devices
C12M23/44 - {Multiple separable units
C12M23/46 - {Means for fastening}
C12M25/02 - {Membranes
C12M29/10 - {Perfusion}

Show less

DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 09/22/2016

Country of Publication:: United States

Language:: English

Citation Formats


                    Hatch, Anson, Abhyankar, Vinay, and Koh, Chung-Yan. Modular assemblies and systems for cell cultures and methods thereof.  United States: N. p., 2021. 
        Web.

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                    Hatch, Anson, Abhyankar, Vinay, & Koh, Chung-Yan. Modular assemblies and systems for cell cultures and methods thereof.  United States.

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                    Hatch, Anson, Abhyankar, Vinay, and Koh, Chung-Yan. Tue .  
        "Modular assemblies and systems for cell cultures and methods thereof".  United States.  https://www.osti.gov/servlets/purl/1823893.

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@article{osti_1823893,

  title        = {Modular assemblies and systems for cell cultures and methods thereof},

  author       = {Hatch, Anson and Abhyankar, Vinay and Koh, Chung-Yan},

  abstractNote = {The present invention relates to modular assemblies and systems for conducting cell analyses. In particular embodiments, an assembly has micron-scale fluidic structures, thereby minimizing sample use, and possesses a modular architecture that facilitates disassembly of the apparatus. Thus, one such modular assembly facilitates on-chip cell growth and on-chip assays; and then, as needed, the assembly can be disassembled to provide direct access to the cells that were incubated and treated within the chip. Methods of making and using such assemblies, as well as systems thereof, are further described herein.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2021},

  month        = {4}

}

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Title: Modular assemblies and systems for cell cultures and methods thereof

Abstract

Citation Formats

Transducer mounting assembly for plumbing fixture patent, April 2015

Microfluidic platform and method of generating a gradient therein patent, December 2008

Cell culture unit and cell culture device including the same patent-application, December 2012

Devices, systems, and methods for microscale isoelectric fractionation patent, August 2016

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Microwell cell-culture device and fabrication method patent, September 2012

Devices and Methods for Pharmacokinetic-Based Cell Culture System patent-application, August 2012

Pumpless microfluidics patent, June 2004

Microscale diffusion immunoassay patent, April 2003

Microscale diffusion immunoassay patent, September 2007

Magnetically actuated fluid handling devices for microfluidic applications patent, June 2002

Use of liquid junction potentials for electrophoresis without applied voltage in a microfluidic channel patent, November 2006

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent, February 2015

Organomimetic devices and methods of use and manufacturing thereof patent-application, November 2016

Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof patent-application, December 2004

Microfluidic Chip for High-Throughput Perfusion-Based Three-Dimensional Cell Culture patent-application, September 2012

Methods, microfluidic devices, and systems for detection of an active enzymatic agent patent, October 2014

Method of patterning particles on an arbitrary substrate and conducting a microfluidic invasion assay patent-application, April 2009

Microfluidic devices and methods including porous polymer monoliths patent, April 2014

Method for voltage-gated protein fractionation patent, April 2012

Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis patent, May 2014

Toxin activity assays, devices, methods and systems therefor patent, April 2016

Nucleic acid arrays and methods of synthesis patent, September 2001

Cell culture apparatus patent, December 2001

Device having microchambers and microfluidics patent, November 2004

Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof patent, June 2014

Preconcentration and separation of analytes in microchannels patent, November 2010

Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis patent, December 2012

Devices, systems, and methods for conducting sandwich assays using sedimentation patent, February 2015

Method for forming polymerized microfluidic devices patent, March 2013

Magnetically actuated fluid handling devices for microfluidic applications patent, July 2002

Method for forming polymerized microfluidic devices patent, November 2011

Microfluidic devices and methods including porous polymer monoliths patent, December 2015

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent, April 2016

Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof patent-application, May 2012

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Transducer mounting assembly for plumbing fixture
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Microfluidic platform and method of generating a gradient therein
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Cell culture unit and cell culture device including the same
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Devices, systems, and methods for microscale isoelectric fractionation
patent, August 2016

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Microwell cell-culture device and fabrication method
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Devices and Methods for Pharmacokinetic-Based Cell Culture System
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Pumpless microfluidics
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Microscale diffusion immunoassay
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Microscale diffusion immunoassay
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Use of liquid junction potentials for electrophoresis without applied voltage in a microfluidic channel
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Organomimetic devices and methods of use and manufacturing thereof
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Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof
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Magnetically actuated fluid handling devices for microfluidic applications
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Method for forming polymerized microfluidic devices
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Microfluidic devices and methods including porous polymer monoliths
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Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
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Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof
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Membrane-separation-type culture device, membrane-separation-type culture kit, stem cell separation method using same, and separation membrane
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