Protein and nucleic acid detection for microfluidic devices

Koh, Chung-Yan; Phaneuf, Christopher

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Title: Protein and nucleic acid detection for microfluidic devices

Abstract

The present invention relates to methods for detecting targets by employing a temperature control system with a microfluidic device. The system allows for non-contact heating by employing an infrared emitter. In some instances, the system can be used in conjunction with a centrifugal microfluidic device. Optionally, a mask can be implemented to provide selective heating of desired assay areas of the device.

Inventors:: Koh, Chung-Yan; Phaneuf, Christopher

Issue Date:: 2021-04-20

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)

OSTI Identifier:: 1823861

Patent Number(s):: 10981174

Application Number:: 16/399,484

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2300/021 - Identification, e.g. bar codes
B01L2300/022 - Transponder chips
B01L2300/0803 - Disc shape
B01L2300/168 - Specific optical properties, e.g. reflective coatings
B01L2300/1844 - using fans
B01L2300/1861 - using radiation
B01L2300/1872 - Infrared light
B01L2300/1894 - Cooling means
B01L2400/0409 - centrifugal forces
B01L3/50273 - {characterised by the means or forces applied to move the fluids
B01L7/52 - {with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
B01L7/525 - {with physical movement of samples between temperature zones}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6813 - Hybridisation assays
C12Q1/6844 - Nucleic acid amplification reactions
C12Q2565/629 - being a microfluidic device

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2021/6439 - {with indicators, stains, dyes, tags, labels, marks}
G01N21/0332 - {with temperature control
G01N21/07 - Centrifugal type cuvettes

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DOE Contract Number:: NA0003525; R01AI098853

Resource Type:: Patent

Resource Relation:: Patent File Date: 04/30/2019

Country of Publication:: United States

Language:: English

Citation Formats


                    Koh, Chung-Yan, and Phaneuf, Christopher. Protein and nucleic acid detection for microfluidic devices.  United States: N. p., 2021. 
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                    Koh, Chung-Yan, & Phaneuf, Christopher. Protein and nucleic acid detection for microfluidic devices.  United States.

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                    Koh, Chung-Yan, and Phaneuf, Christopher. Tue .  
        "Protein and nucleic acid detection for microfluidic devices".  United States.  https://www.osti.gov/servlets/purl/1823861.

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@article{osti_1823861,

  title        = {Protein and nucleic acid detection for microfluidic devices},

  author       = {Koh, Chung-Yan and Phaneuf, Christopher},

  abstractNote = {The present invention relates to methods for detecting targets by employing a temperature control system with a microfluidic device. The system allows for non-contact heating by employing an infrared emitter. In some instances, the system can be used in conjunction with a centrifugal microfluidic device. Optionally, a mask can be implemented to provide selective heating of desired assay areas of the device.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2021},

  month        = {4}

}

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Devices, systems, and methods for detecting nucleic acids using sedimentation

Patent Koh, Chung-Yan; Schaff, Ulrich Y.; Sommer, Gregory J.

Embodiments of the present invention are directed toward devices, systems, and method for conducting nucleic acid purification and quantification using sedimentation. In one example, a method includes generating complexes which bind to a plurality of beads in a fluid sample, individual ones of the complexes comprising a nucleic acid molecule such as DNA or RNA and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transportingmore » « less
Full Text Available
Devices, systems, and methods for detecting nucleic acids using sedimentation

Patent Koh, Chung-Yan; Schaff, Ulrich Y.; Sommer, Gregory J.

Embodiments of the present invention are directed toward devices, systems, and method for conducting nucleic acid purification and quantification using sedimentation. In one example, a method includes generating complexes which bind to a plurality of beads in a fluid sample, individual ones of the complexes comprising a nucleic acid molecule such as DNA or RNA and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transportingmore » « less
Full Text Available

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Title: Protein and nucleic acid detection for microfluidic devices

Abstract

Citation Formats

Microparticle-based methods and systems and applications thereof patent-application, December 2005

Integrated planar microfluidic bioanalytical systems patent-application, August 2006

Method for Separating Cells patent-application, May 2008

Diagnostic tests and kits for Clostridium difficile patent, January 2003

Systems, Devices, and Methods For Agglutination Assays Using Sedimentation patent-application, March 2016

Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid patent-application, February 2018

Method and apparatus for measuring blood constituent counts patent, July 1987

DNA purification and isolation using magnetic particles patent, January 1998

Method for retrieving delta9-THC from oral fluid patent-application, April 2006

Method and Apparatus For Precise Transfer and Manipulation Of Fluids By Centrifugal and Or Capillary Forces patent-application, January 2009

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto patent, January 2007

Class characterization of circulating cancer cells isolated from body fluids and methods of use patent-application, July 2002

Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species patent-application, October 2003

Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay patent, June 1997

Centrifugal force based microfluidic device, microfluidic system including the same, and method of determining home position of the microfluidic device patent, July 2010

Toxin Activity Assays, Devices, Methods And Systems Therefor patent-application, June 2016

System and method for detecting components of a mixture including a valving scheme for competition assays patent, July 2017

Multichannel control in microfluidics patent-application, October 2002

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent, February 2015

Multistation, Single Channel Analytical Photometer and Method of Use patent, January 1971

Analytical methods and compositions patent-application, November 2002

Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids patent, February 2008

Multi-parameter assays including analysis discs and methods relating thereto patent-application, October 2002

Microfluidic devices and methods patent-application, January 2003

Microfluidic Devices, Systems, And Methods For Quantifying Particles Using Centrifugal Force patent-application, December 2015

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system patent, November 2001

Diagnostic Analyzers With Pretreatment Carousels and Related Methods patent-application, September 2014

System and method for detecting components of a mixture including tooth elements for alignment patent, November 2016

Separation of solid and liquid components of mixtures patent, November 1978

Devices, systems, and methods for conducting sandwich assays using sedimentation patent, February 2015

Microfluidic devices, systems, and methods for quantifying particles using centrifugal force patent, November 2015

Apparatus and method for measuring white blood cell and platelet concentrations in blood patent, May 1979

Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol patent, July 2010

Microfluidic particle-analysis systems patent-application, April 2004

Novel multi-analyte optical computing system patent-application, December 2010

System and method for detecting components of a mixture including a valving scheme for competition assays patent, September 2017

Loading Disk for Photometric Analyzer of Rotary Cuvette Type patent, July 1973

Multi-parameter assays including analysis discs and methods relating thereto patent, April 2006

Separation Device patent-application, May 2010

Centrifugation Apparatus For Containers Of Biological Material patent-application, February 2011

Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces patent, December 2012

Thermoelectric sensor for analytes in a gas and related method patent-application, March 2008

Method for separating the cellular components of blood samples patent, July 1989

Immunoassay for tetrahydrocannabinol metabolites patent, May 1989

Reagents for labeling biomolecules having aldehyde or ketone Moieties patent-application, September 2002

Microporation of tissue for delivery of bioactive agents patent-application, April 2003

Plastic microfluidics enabling two-dimensional protein separations in proteome analysis patent-application, November 2002

Density-based cell detection system patent, March 2010

Devices, systems, and methods for detecting nucleic acids using sedimentation patent-application, March 2018

Protecting agent patent-application, August 2005

Methods for fragmenting DNA patent-application, September 2005

Apparatus and method for carrying out analysis of samples patent, April 1999

Class characterization of circulating cancer cells isolated from body fluids and methods of use patent, November 2005

Systems, devices, and methods for agglutination assays using sedimentation patent, January 2016

Assay of blood or other biologic samples for target analytes patent, June 1997

Method for detecting analytes in a sample patent-application, December 2009

Delta-9-tetrahydrocannabinol detection method patent, September 2010

Toxin activity assays, devices, methods and systems therefor patent, April 2016

Centrifuge with removable core for scalable centrifugation patent-application, September 2005

Centrifugal hematology disposable patent, November 2000

Microfluidics devices and methods for performing cell based assays patent-application, August 2002

Microfluidic particle-analysis systems patent, December 2007

Centrifugal Separation System patent-application, August 2009

Heterogeneous binding assay patent, April 1987

Monolithic microfluidic concentrators and mixers patent, May 2005

Compact disk based platform for separating and detecting immunomagnetic bead labeled cells patent-application, June 2010

Devices and Method For Using Centripetal Acceleration To Drive Fluid Movement In A Microfluidics System With On-Board Informatics patent-application, December 2001

Method of separation employing magnetic particles and second medium patent, January 1994

Systems and Methods for Handling Microfluidic Droplets patent-application, October 2013

Assay system and method for conducting assays patent, March 1999

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent, April 2016

Method Of Detecting Analyte-Molecule Interactions patent-application, June 2008

Method For Isolating Nucleic Acids Comprising The Use Of Ethylene Glycol Multimers patent-application, March 2009

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device patent, November 1985

Method for separating cells patent-application, July 2003

Quantitative detection of pathogens in centrifugal microfluidic disks patent-application, February 2018

Microparticle-based methods and systems and applications thereof
patent-application, December 2005

Integrated planar microfluidic bioanalytical systems
patent-application, August 2006

Method for Separating Cells
patent-application, May 2008

Diagnostic tests and kits for Clostridium difficile
patent, January 2003

Systems, Devices, and Methods For Agglutination Assays Using Sedimentation
patent-application, March 2016

Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
patent-application, February 2018

Method and apparatus for measuring blood constituent counts
patent, July 1987

DNA purification and isolation using magnetic particles
patent, January 1998

Method for retrieving delta9-THC from oral fluid
patent-application, April 2006

Method and Apparatus For Precise Transfer and Manipulation Of Fluids By Centrifugal and Or Capillary Forces
patent-application, January 2009

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
patent, January 2007

Class characterization of circulating cancer cells isolated from body fluids and methods of use
patent-application, July 2002

Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
patent-application, October 2003

Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
patent, June 1997

Centrifugal force based microfluidic device, microfluidic system including the same, and method of determining home position of the microfluidic device
patent, July 2010

Toxin Activity Assays, Devices, Methods And Systems Therefor
patent-application, June 2016

System and method for detecting components of a mixture including a valving scheme for competition assays
patent, July 2017

Multichannel control in microfluidics
patent-application, October 2002

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
patent, February 2015

Multistation, Single Channel Analytical Photometer and Method of Use
patent, January 1971

Analytical methods and compositions
patent-application, November 2002

Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
patent, February 2008

Multi-parameter assays including analysis discs and methods relating thereto
patent-application, October 2002

Microfluidic devices and methods
patent-application, January 2003

Microfluidic Devices, Systems, And Methods For Quantifying Particles Using Centrifugal Force
patent-application, December 2015

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
patent, November 2001

Diagnostic Analyzers With Pretreatment Carousels and Related Methods
patent-application, September 2014

System and method for detecting components of a mixture including tooth elements for alignment
patent, November 2016

Separation of solid and liquid components of mixtures
patent, November 1978

Devices, systems, and methods for conducting sandwich assays using sedimentation
patent, February 2015

Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
patent, November 2015

Apparatus and method for measuring white blood cell and platelet concentrations in blood
patent, May 1979

Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol
patent, July 2010

Microfluidic particle-analysis systems
patent-application, April 2004

Novel multi-analyte optical computing system
patent-application, December 2010

System and method for detecting components of a mixture including a valving scheme for competition assays
patent, September 2017

Loading Disk for Photometric Analyzer of Rotary Cuvette Type
patent, July 1973

Multi-parameter assays including analysis discs and methods relating thereto
patent, April 2006

Separation Device
patent-application, May 2010

Centrifugation Apparatus For Containers Of Biological Material
patent-application, February 2011

Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces
patent, December 2012

Thermoelectric sensor for analytes in a gas and related method
patent-application, March 2008

Method for separating the cellular components of blood samples
patent, July 1989

Immunoassay for tetrahydrocannabinol metabolites
patent, May 1989

Reagents for labeling biomolecules having aldehyde or ketone Moieties
patent-application, September 2002

Microporation of tissue for delivery of bioactive agents
patent-application, April 2003

Plastic microfluidics enabling two-dimensional protein separations in proteome analysis
patent-application, November 2002

Density-based cell detection system
patent, March 2010

Devices, systems, and methods for detecting nucleic acids using sedimentation
patent-application, March 2018

Protecting agent
patent-application, August 2005

Methods for fragmenting DNA
patent-application, September 2005

Apparatus and method for carrying out analysis of samples
patent, April 1999

Class characterization of circulating cancer cells isolated from body fluids and methods of use
patent, November 2005

Systems, devices, and methods for agglutination assays using sedimentation
patent, January 2016

Assay of blood or other biologic samples for target analytes
patent, June 1997

Method for detecting analytes in a sample
patent-application, December 2009

Delta-9-tetrahydrocannabinol detection method
patent, September 2010

Toxin activity assays, devices, methods and systems therefor
patent, April 2016

Centrifuge with removable core for scalable centrifugation
patent-application, September 2005

Centrifugal hematology disposable
patent, November 2000

Microfluidics devices and methods for performing cell based assays
patent-application, August 2002

Microfluidic particle-analysis systems
patent, December 2007

Centrifugal Separation System
patent-application, August 2009

Heterogeneous binding assay
patent, April 1987

Monolithic microfluidic concentrators and mixers
patent, May 2005

Compact disk based platform for separating and detecting immunomagnetic bead labeled cells
patent-application, June 2010

Devices and Method For Using Centripetal Acceleration To Drive Fluid Movement In A Microfluidics System With On-Board Informatics
patent-application, December 2001

Method of separation employing magnetic particles and second medium
patent, January 1994

Systems and Methods for Handling Microfluidic Droplets
patent-application, October 2013

Assay system and method for conducting assays
patent, March 1999

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
patent, April 2016

Method Of Detecting Analyte-Molecule Interactions
patent-application, June 2008

Method For Isolating Nucleic Acids Comprising The Use Of Ethylene Glycol Multimers
patent-application, March 2009

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device
patent, November 1985

Method for separating cells
patent-application, July 2003

Quantitative detection of pathogens in centrifugal microfluidic disks
patent-application, February 2018