Gene targets for improved enzyme production in fungi
Abstract
Fungi that are genetically inactivated for the mstC gene (or a homolog thereof) are provided, which can also be genetically modified to increase production of heterologous proteins from a glucoamylase promoter. Methods of using these fungi, for example to degrade a biomass, are also provided.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1805568
- Patent Number(s):
- 10934551
- Application Number:
- 16/163,509
- Assignee:
- Battelle Memorial Institute (Richland, WA); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AC02-05CH11231; AC05-76RL01830
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 10/17/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Baker, Scott E., Magnuson, Jon K., Reilly, Mike C., Kim, Joonhoon, Gladden, John M., and Lynn, Joe J. Gene targets for improved enzyme production in fungi. United States: N. p., 2021.
Web.
Baker, Scott E., Magnuson, Jon K., Reilly, Mike C., Kim, Joonhoon, Gladden, John M., & Lynn, Joe J. Gene targets for improved enzyme production in fungi. United States.
Baker, Scott E., Magnuson, Jon K., Reilly, Mike C., Kim, Joonhoon, Gladden, John M., and Lynn, Joe J. Tue .
"Gene targets for improved enzyme production in fungi". United States. https://www.osti.gov/servlets/purl/1805568.
@article{osti_1805568,
title = {Gene targets for improved enzyme production in fungi},
author = {Baker, Scott E. and Magnuson, Jon K. and Reilly, Mike C. and Kim, Joonhoon and Gladden, John M. and Lynn, Joe J.},
abstractNote = {Fungi that are genetically inactivated for the mstC gene (or a homolog thereof) are provided, which can also be genetically modified to increase production of heterologous proteins from a glucoamylase promoter. Methods of using these fungi, for example to degrade a biomass, are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {3}
}
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Works referenced in this record:
Ionic Liquid-Tolerant Cellulase Enzymes
patent-application,
- Gladden, John; Park, Joshua; Singer, Steven
- US Patent Application 14/612201; 20150218543