Title: Separation of nanoparticles via acoustofluidic flow relocation

Abstract

The present disclosure describes a method of separating particles using a combination of acoustophoresis and acoustic fluid relocation. The disclosure also describes a microfluidic device that can be used to separate particles using a combination of acoustophoresis and acoustic fluid relocation. The disclosure describes methods of separating nanoparticles, microparticles, nanoparticles from microparticles, and micron-sized particles from sub-micron-sized particles.

Inventors:

Piyasena, Menake E.; Gautam, Gayatri P.

Issue Date:

2021-03-02

Research Org.:

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1805558

Patent Number(s):

10933429

Application Number:

15/919,886

Assignee:

New Mexico Tech University Research Park Corporation (Socorro, NM)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY

A61M1/3678 - {Separation of cells using wave pressure
A61M2205/0244 - Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L2200/0647 - Handling flowable solids, e.g. microscopic beads, cells, particles
B01L2400/0436 - acoustic forces, e.g. surface acoustic waves [SAW]
B01L3/502753 - {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation

B - PERFORMING OPERATIONS B03 - SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS B03B - SEPARATING SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS

B03B5/02 - using shaken, pulsated or stirred beds as the principal means of separation

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/491 - {by separating the blood components

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DOE Contract Number:  

AC04-94AL85000; AC52-06NA25396

Resource Type:

Patent

Resource Relation:

Patent File Date: 03/13/2018

Country of Publication:

United States

Language:

English