Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth
Abstract
A sensor array for simultaneously measuring electrophysiological responses and contractility responses of a tissue includes: a substrate; a multi-electrode array (MEA) disposed in or on the substrate; and a plurality of interdigitized electrodes (IDEs) disposed in or on the substrate. The MEA and the IDEs are interpenetrating within a plane substantially parallel to an upper surface of the substrate. Systems for measuring such responses using the sensor array may also include contacts and/or connectors for interfacing with external control devices, electrodes, and cell culture components such as a chamber and lid. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1805496
- Patent Number(s):
- 10914722
- Application Number:
- 15/901,766
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 02/21/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Qian, Fang, Huang, Chienjin, Ivanovskaya, Anna Nikolaevna, Kulp, Kris, and Wheeler, Elizabeth K. Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth. United States: N. p., 2021.
Web.
Qian, Fang, Huang, Chienjin, Ivanovskaya, Anna Nikolaevna, Kulp, Kris, & Wheeler, Elizabeth K. Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth. United States.
Qian, Fang, Huang, Chienjin, Ivanovskaya, Anna Nikolaevna, Kulp, Kris, and Wheeler, Elizabeth K. Tue .
"Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth". United States. https://www.osti.gov/servlets/purl/1805496.
@article{osti_1805496,
title = {Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth},
author = {Qian, Fang and Huang, Chienjin and Ivanovskaya, Anna Nikolaevna and Kulp, Kris and Wheeler, Elizabeth K.},
abstractNote = {A sensor array for simultaneously measuring electrophysiological responses and contractility responses of a tissue includes: a substrate; a multi-electrode array (MEA) disposed in or on the substrate; and a plurality of interdigitized electrodes (IDEs) disposed in or on the substrate. The MEA and the IDEs are interpenetrating within a plane substantially parallel to an upper surface of the substrate. Systems for measuring such responses using the sensor array may also include contacts and/or connectors for interfacing with external control devices, electrodes, and cell culture components such as a chamber and lid. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {2}
}