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Title: Fermentation process using yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol

Abstract

Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.

Inventors:
; ; ; ; ; ; ;
Issue Date:
Research Org.:
Cargill, Inc., Wayzata, MN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1805414
Patent Number(s):
10899544
Application Number:
15/941,274
Assignee:
Cargill, Incorporated (Wayzata, MN)
DOE Contract Number:  
FC36-03GO13145
Resource Type:
Patent
Resource Relation:
Patent File Date: 03/30/2018
Country of Publication:
United States
Language:
English

Citation Formats

Dundon, Catherine Asleson, Suominen, Pirrko, Aristidou, Aristos, Rush, Brian J., Koivuranta, Kari, Hause, Benjamin Matthew, McMullin, Thomas William, and Roberg-Perez, Kevin. Fermentation process using yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol. United States: N. p., 2021. Web.
Dundon, Catherine Asleson, Suominen, Pirrko, Aristidou, Aristos, Rush, Brian J., Koivuranta, Kari, Hause, Benjamin Matthew, McMullin, Thomas William, & Roberg-Perez, Kevin. Fermentation process using yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol. United States.
Dundon, Catherine Asleson, Suominen, Pirrko, Aristidou, Aristos, Rush, Brian J., Koivuranta, Kari, Hause, Benjamin Matthew, McMullin, Thomas William, and Roberg-Perez, Kevin. Tue . "Fermentation process using yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol". United States. https://www.osti.gov/servlets/purl/1805414.
@article{osti_1805414,
title = {Fermentation process using yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol},
author = {Dundon, Catherine Asleson and Suominen, Pirrko and Aristidou, Aristos and Rush, Brian J. and Koivuranta, Kari and Hause, Benjamin Matthew and McMullin, Thomas William and Roberg-Perez, Kevin},
abstractNote = {Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {1}
}