Small molecule dye for molecular imaging and photothermal therapy
Abstract
Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.
- Inventors:
- Issue Date:
- Research Org.:
- Stanford Univ., Palo Alto, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1805394
- Patent Number(s):
- 10894121
- Application Number:
- 16/186,947
- Assignee:
- The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)
- DOE Contract Number:
- SC0008397
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 11/12/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Cheng, Zhen, Hong, Xuechuan, Dai, Hongjie, Chen, Hao, Antaris, Alexander L., and Cheng, Ken. Small molecule dye for molecular imaging and photothermal therapy. United States: N. p., 2021.
Web.
Cheng, Zhen, Hong, Xuechuan, Dai, Hongjie, Chen, Hao, Antaris, Alexander L., & Cheng, Ken. Small molecule dye for molecular imaging and photothermal therapy. United States.
Cheng, Zhen, Hong, Xuechuan, Dai, Hongjie, Chen, Hao, Antaris, Alexander L., and Cheng, Ken. Tue .
"Small molecule dye for molecular imaging and photothermal therapy". United States. https://www.osti.gov/servlets/purl/1805394.
@article{osti_1805394,
title = {Small molecule dye for molecular imaging and photothermal therapy},
author = {Cheng, Zhen and Hong, Xuechuan and Dai, Hongjie and Chen, Hao and Antaris, Alexander L. and Cheng, Ken},
abstractNote = {Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {1}
}