Title: Host cells and methods for producing diacid compounds

Abstract

The present invention provides for a genetically modified host cell and related methods and materials for the biocatalytic production of an α,ω-dicarboxylic acids (DCAs) and/or mono-methyl ester derivatives of dicarboxylic acids (DCAMMEs).

Inventors:

Haushalter, Robert W.; Keasling, Jay D.

Issue Date:

2020-12-29

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1771763

Patent Number(s):

10876139

Application Number:

16/423,402

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N9/1007 - {Methyltransferases
C12N9/16 - acting on ester bonds

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P17/08 - containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
C12P7/44 - Polycarboxylic acids
C12P7/6409 - {Fatty acids}
C12P7/6436 - {Fatty acid esters}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y201/01197 - Malonyl-CoA O-methyltransferase
C12Y301/02 - Thioester hydrolases

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DOE Contract Number:  

AC02-05CH11231

Resource Type:

Patent

Resource Relation:

Patent File Date: 05/28/2019

Country of Publication:

United States

Language:

English