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Title: Selective high-affinity polydentate ligands and methods of making such

Abstract

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); Univ. of California, Livermore, CA (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1771755
Patent Number(s):
10874678
Application Number:
16/289,464
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA); The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC52-07NA27344; CA047829
Resource Type:
Patent
Resource Relation:
Patent File Date: 02/28/2019
Country of Publication:
United States
Language:
English

Citation Formats

DeNardo, Sally J., DeNardo, Gerald L., and Balhorn, Rodney L. Selective high-affinity polydentate ligands and methods of making such. United States: N. p., 2020. Web.
DeNardo, Sally J., DeNardo, Gerald L., & Balhorn, Rodney L. Selective high-affinity polydentate ligands and methods of making such. United States.
DeNardo, Sally J., DeNardo, Gerald L., and Balhorn, Rodney L. Tue . "Selective high-affinity polydentate ligands and methods of making such". United States. https://www.osti.gov/servlets/purl/1771755.
@article{osti_1771755,
title = {Selective high-affinity polydentate ligands and methods of making such},
author = {DeNardo, Sally J. and DeNardo, Gerald L. and Balhorn, Rodney L.},
abstractNote = {This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {12}
}

Works referenced in this record:

Bispecific antibodies for retargeting anticancer cytotoxic lymphocytes
patent-application, May 2001


Structure-based hepatitis c virus drug design
patent-application, September 2003


Spanning binding sites on allosteric proteins with polymer-linked ligand dimers
journal, October 1998


Discovering High-Affinity Ligands for Proteins: SAR by NMR
journal, November 1996


Bispecific antibodies that bind to vegf receptors
patent-application, December 2004


Radioimmunotherapy of lymphoma using anti-CD20
patent, January 1997


Low-dose, Fractionated Radioimmunotherapy for B-cell Malignancies using 131 I-LYM-1 Antibody
journal, January 1998


Nanomolecular HLA-DR10 Antibody Mimics: A Potent System for Molecular Targeted Therapy and Imaging
journal, December 2008


Bispecific antibodies
patent-application, January 2006


Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2
patent-application, October 2002


Bispecific antibodies for inducing apoptosis of tumor and diseased cells
patent-application, April 2005


Characteristics of dimeric (bis) bidentate selective high affinity ligands as HLA-DR10 beta antibody mimics targeting non-Hodgkin's lymphoma
journal, October 2007


Use of bispecific antibodies to regulate immune responses
patent-application, April 2003


Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
journal, January 2001


Disruption of Anthrax Toxin Binding with the Use of Human Antibodies and Competitive Inhibitors
journal, June 1999


Treatment of B cell malignancies with131I LYM-1 monoclonal antibodies
journal, January 1988


Update: Systemic Radiotherapy Can Cure Lymphoma: A Paradigm for Other Malignancies?
journal, August 2008


Structure-Based Design of a Bispecific Receptor Mimic That Inhibits T Cell Responses to a Superantigen
journal, April 2001


Lead discovery using molecular docking
journal, August 2002


Antigenic epitopes with LYM-1 reactivity and uses thereof
patent, April 2001


AB5 toxins: structures and inhibitor design
journal, December 2000


Synthesis and Radiolabeling of Selective High-Affinity Ligands Designed to Target Non-Hodgkin's Lymphoma and Leukemia
journal, May 2007


Direct Antilymphoma Activity of Novel, First-Generation "Antibody Mimics" that Bind HLA-DR10-Positive Non-Hodgkin's Lymphoma Cells
journal, December 2006


HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance
journal, February 2017


Humanization and characterization of the anti-HLA-DR antibody 1D10
journal, January 2001


Selective high affinity polydentate ligands and methods of making such
patent-application, April 2006


Bispecific antibodies
patent-application, June 2005


Identification of Novel Small Molecules That Bind to Two Different Sites on the Surface of Tetanus Toxin C Fragment
journal, October 2002


Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells
journal, January 2009


Destruction of contaminating tumor cells in stem cell transplants using bispecific antibodies
patent, November 1999


Method of enhancing the biodistribution of antibody for localization in lesions
patent, May 1990


Selective high-affinity polydentate ligands and methods of making such
patent, September 2013