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Title: Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds

Abstract

Described herein are bacteriochlorins comprising an annulated isocyclic ring such as a compound Formula I: or a metal conjugate thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, and Z are each as defined herein. Also described are methods and intermediates for the synthesis of bacteriochlorins comprising an annulated isocyclic ring, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as, e.g., luminescent compounds in flow cytometry, and/or as active agents in photodynamic therapy (PDT).

Inventors:
;
Issue Date:
Research Org.:
North Carolina State Univ., Raleigh, NC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1771632
Patent Number(s):
10836774
Application Number:
16/464,728
Assignee:
North Carolina State University (Raleigh, NC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG02-05ER15661
Resource Type:
Patent
Resource Relation:
Patent File Date: 11/27/2017
Country of Publication:
United States
Language:
English

Citation Formats

Lindsey, Jonathan S., and Zhang, Shaofei. Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds. United States: N. p., 2020. Web.
Lindsey, Jonathan S., & Zhang, Shaofei. Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds. United States.
Lindsey, Jonathan S., and Zhang, Shaofei. Tue . "Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds". United States. https://www.osti.gov/servlets/purl/1771632.
@article{osti_1771632,
title = {Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds},
author = {Lindsey, Jonathan S. and Zhang, Shaofei},
abstractNote = {Described herein are bacteriochlorins comprising an annulated isocyclic ring such as a compound Formula I: or a metal conjugate thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, and Z are each as defined herein. Also described are methods and intermediates for the synthesis of bacteriochlorins comprising an annulated isocyclic ring, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as, e.g., luminescent compounds in flow cytometry, and/or as active agents in photodynamic therapy (PDT).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {11}
}

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