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Title: Viral inhibitory nucleotide sequences and vaccines

Abstract

The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Institute for Advanced Study, Princeton, NJ (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1771553
Patent Number(s):
10815277
Application Number:
15/228,451
Assignee:
Institute for Advanced Study (Princeton, NJ)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
FG02-90ER40542
Resource Type:
Patent
Resource Relation:
Patent File Date: 08/04/2016
Country of Publication:
United States
Language:
English

Citation Formats

Rabadan, Raul, Krasnitz, Michael, Robins, Harlan S., Witten, Daniela, and Levine, Arnold J. Viral inhibitory nucleotide sequences and vaccines. United States: N. p., 2020. Web.
Rabadan, Raul, Krasnitz, Michael, Robins, Harlan S., Witten, Daniela, & Levine, Arnold J. Viral inhibitory nucleotide sequences and vaccines. United States.
Rabadan, Raul, Krasnitz, Michael, Robins, Harlan S., Witten, Daniela, and Levine, Arnold J. Tue . "Viral inhibitory nucleotide sequences and vaccines". United States. https://www.osti.gov/servlets/purl/1771553.
@article{osti_1771553,
title = {Viral inhibitory nucleotide sequences and vaccines},
author = {Rabadan, Raul and Krasnitz, Michael and Robins, Harlan S. and Witten, Daniela and Levine, Arnold J.},
abstractNote = {The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {10}
}

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