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Title: Detection of active and latent infections with microfluidic devices and systems thereof

Abstract

The present invention relates to methods of detecting one or more targets of interest in a sample. In one instance, the target can be correlated to an active infection (e.g., by a virus and/or a bacterium). Methods can include treating the sample with a dissociation agent, thereby releasing the target of interest for more accurate detection (e.g., by use of a sedimentation-based centrifugal microfluidic devices). Also described herein are microfluidic devices and systems for use with a dissociation agent.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1735311
Patent Number(s):
10786811
Application Number:
15/785,708
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM); Litvinov, Julia (Galveston, TX)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
DOE Contract Number:  
NA0003525
Resource Type:
Patent
Resource Relation:
Patent File Date: 10/17/2017
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Koh, Chung-Yan, Singh, Anup K., and Litvinov, Julia. Detection of active and latent infections with microfluidic devices and systems thereof. United States: N. p., 2020. Web.
Koh, Chung-Yan, Singh, Anup K., & Litvinov, Julia. Detection of active and latent infections with microfluidic devices and systems thereof. United States.
Koh, Chung-Yan, Singh, Anup K., and Litvinov, Julia. Tue . "Detection of active and latent infections with microfluidic devices and systems thereof". United States. https://www.osti.gov/servlets/purl/1735311.
@article{osti_1735311,
title = {Detection of active and latent infections with microfluidic devices and systems thereof},
author = {Koh, Chung-Yan and Singh, Anup K. and Litvinov, Julia},
abstractNote = {The present invention relates to methods of detecting one or more targets of interest in a sample. In one instance, the target can be correlated to an active infection (e.g., by a virus and/or a bacterium). Methods can include treating the sample with a dissociation agent, thereby releasing the target of interest for more accurate detection (e.g., by use of a sedimentation-based centrifugal microfluidic devices). Also described herein are microfluidic devices and systems for use with a dissociation agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {9}
}

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