Methods for delineating cellular regions and classifying regions of histopathology and microanatomy
Abstract
Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1735267
- Patent Number(s):
- 10776606
- Application Number:
- 14/493,208
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G06 - COMPUTING G06K - RECOGNITION OF DATA
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 09/22/2014
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Parvin, Bahram, Chang, Hang, and Zhou, Yin. Methods for delineating cellular regions and classifying regions of histopathology and microanatomy. United States: N. p., 2020.
Web.
Parvin, Bahram, Chang, Hang, & Zhou, Yin. Methods for delineating cellular regions and classifying regions of histopathology and microanatomy. United States.
Parvin, Bahram, Chang, Hang, and Zhou, Yin. Tue .
"Methods for delineating cellular regions and classifying regions of histopathology and microanatomy". United States. https://www.osti.gov/servlets/purl/1735267.
@article{osti_1735267,
title = {Methods for delineating cellular regions and classifying regions of histopathology and microanatomy},
author = {Parvin, Bahram and Chang, Hang and Zhou, Yin},
abstractNote = {Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {9}
}
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