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Title: Precise microbiota engineering at the cellular level

Abstract

Stably immunized cells and methods of making stably immunized cells are provided. Methods of altering the microbiota of an ecological environment are provided. Methods of modifying target chromosomes are provided. Methods of delivering genetic material to target cells are provided.

Inventors:
;
Issue Date:
Research Org.:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1735182
Patent Number(s):
10752906
Application Number:
15/034,682
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FG02-02ER63445
Resource Type:
Patent
Resource Relation:
Patent File Date: 11/05/2014
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Esvelt, Kevin M., and Yaung, Stephanie. Precise microbiota engineering at the cellular level. United States: N. p., 2020. Web.
Esvelt, Kevin M., & Yaung, Stephanie. Precise microbiota engineering at the cellular level. United States.
Esvelt, Kevin M., and Yaung, Stephanie. Tue . "Precise microbiota engineering at the cellular level". United States. https://www.osti.gov/servlets/purl/1735182.
@article{osti_1735182,
title = {Precise microbiota engineering at the cellular level},
author = {Esvelt, Kevin M. and Yaung, Stephanie},
abstractNote = {Stably immunized cells and methods of making stably immunized cells are provided. Methods of altering the microbiota of an ecological environment are provided. Methods of modifying target chromosomes are provided. Methods of delivering genetic material to target cells are provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {8}
}

Works referenced in this record:

Concerning RNA-guided gene drives for the alteration of wild populations
journal, July 2014


A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
journal, June 2012


Genomeā€scale engineering for systems and synthetic biology
journal, January 2013


Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
journal, September 2013


Lactococcus CRISPR-Cas Sequences
patent-application, October 2013


Rewriting a genome
journal, March 2013


Methods And Compositions For Rna-Directed Target Dna Modification And For Rna-Directed Modulation Of Transcription
patent-application, March 2014


CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome
journal, June 2012