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Title: Biomolecular patterning of three dimensional tissue scaffolds

Abstract

The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.

Inventors:
; ; ;
Issue Date:
Research Org.:
Univ. of Illinois at Urbana-Champaign, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1735120
Patent Number(s):
10736992
Application Number:
14/001,327
Assignee:
The Board of Trustees of the University of Illinois (Urbana, IL)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FG02-07ER46453; FG02-07ER46471
Resource Type:
Patent
Resource Relation:
Patent File Date: 02/27/2012
Country of Publication:
United States
Language:
English

Citation Formats

Bailey, Ryan C., Harley, Brendan A., Martin, Teresa A., and Caliari, Steven R. Biomolecular patterning of three dimensional tissue scaffolds. United States: N. p., 2020. Web.
Bailey, Ryan C., Harley, Brendan A., Martin, Teresa A., & Caliari, Steven R. Biomolecular patterning of three dimensional tissue scaffolds. United States.
Bailey, Ryan C., Harley, Brendan A., Martin, Teresa A., and Caliari, Steven R. Tue . "Biomolecular patterning of three dimensional tissue scaffolds". United States. https://www.osti.gov/servlets/purl/1735120.
@article{osti_1735120,
title = {Biomolecular patterning of three dimensional tissue scaffolds},
author = {Bailey, Ryan C. and Harley, Brendan A. and Martin, Teresa A. and Caliari, Steven R.},
abstractNote = {The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {8}
}

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