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Title: Synthetic methylotrophy to liquid fuels and chemicals

Abstract

A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.

Inventors:
; ; ; ; ; ; ; ;
Issue Date:
Research Org.:
Univ. of Delaware, Newark, DE (United States)
Sponsoring Org.:
USDOE Advanced Research Projects Agency - Energy (ARPA-E)
OSTI Identifier:
1735043
Patent Number(s):
10717964
Application Number:
16/042,257
Assignee:
University of Delaware (Newark, DE)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
AR0000432
Resource Type:
Patent
Resource Relation:
Patent File Date: 07/23/2018
Country of Publication:
United States
Language:
English

Citation Formats

Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, and Antoniewicz, Maciek. Synthetic methylotrophy to liquid fuels and chemicals. United States: N. p., 2020. Web.
Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, & Antoniewicz, Maciek. Synthetic methylotrophy to liquid fuels and chemicals. United States.
Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, and Antoniewicz, Maciek. Tue . "Synthetic methylotrophy to liquid fuels and chemicals". United States. https://www.osti.gov/servlets/purl/1735043.
@article{osti_1735043,
title = {Synthetic methylotrophy to liquid fuels and chemicals},
author = {Papoutsakis, Eleftherios T. and Nicolaou, Sergios and Fast, Alan and Falara, Vasiliki and Bennett, Robert Kyle and Whitaker, William Brian and Sandoval, Nicholas Richard and Gonzalez, Jacqueline and Antoniewicz, Maciek},
abstractNote = {A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {7}
}

Works referenced in this record:

Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
patent, April 2014


Methods and systems for chemoautotrophic production of organic compounds
patent, January 2013


Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
patent, April 2014


Methods for increasing product yields
patent, January 2014


Microorganisms for the production of 1,4-butanediol
patent, May 2012


Synthetic methylotrophy to liquid fuels and chemicals
patent, August 2018