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Title: Synthetic methylotrophy to liquid fuels and chemicals

Abstract

A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.

Inventors:
; ; ; ; ; ; ; ;
Issue Date:
Research Org.:
Univ. of Delaware, Newark, DE (United States)
Sponsoring Org.:
USDOE Advanced Research Projects Agency - Energy (ARPA-E)
OSTI Identifier:
1735043
Patent Number(s):
10717964
Application Number:
16/042,257
Assignee:
University of Delaware (Newark, DE)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
AR0000432
Resource Type:
Patent
Resource Relation:
Patent File Date: 07/23/2018
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 09 BIOMASS FUELS

Citation Formats

Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, and Antoniewicz, Maciek. Synthetic methylotrophy to liquid fuels and chemicals. United States: N. p., 2020. Web.
Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, & Antoniewicz, Maciek. Synthetic methylotrophy to liquid fuels and chemicals. United States.
Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, and Antoniewicz, Maciek. Tue . "Synthetic methylotrophy to liquid fuels and chemicals". United States. https://www.osti.gov/servlets/purl/1735043.
@article{osti_1735043,
title = {Synthetic methylotrophy to liquid fuels and chemicals},
author = {Papoutsakis, Eleftherios T. and Nicolaou, Sergios and Fast, Alan and Falara, Vasiliki and Bennett, Robert Kyle and Whitaker, William Brian and Sandoval, Nicholas Richard and Gonzalez, Jacqueline and Antoniewicz, Maciek},
abstractNote = {A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 21 00:00:00 EDT 2020},
month = {Tue Jul 21 00:00:00 EDT 2020}
}

Works referenced in this record:

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Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
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Identification of Isoprene Synthase Variants with Improved Properties for the Production of Isoprene
patent-application, December 2013


Methods and Organisms for Utilizing Synthesis Gas or Other Gaseous Carbon Sources and Methanol
patent-application, March 2013


Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
patent, April 2014


Synthetic methylotrophy to liquid fuels and chemicals
patent, August 2018


Microorganisms and Methods for Conversion of Syngas and Other Carbon Sources to Useful Products
patent-application, May 2014


Hyperphotosynthetic Organisms
patent-application, August 2009


Methylotrophic Bacterium for the Production of Recombinant Proteins and Other Proteins
patent-application, June 2003


Method for Producing Target Substance
patent-application, June 2003


Method for Producing Target Substance
patent-application, September 2004