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Title: Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds

Abstract

Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals. Advantageously, the catalytic homopiperazine-based ligand-metal complexes are formed using inexpensive, readily-available precursor materials, and may be utilized to neutralize toxins without relying on damaging caustic reactants or environmentally unfriendly organic solvents.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1735042
Patent Number(s):
10717713
Application Number:
16/136,057
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 09/19/2018
Country of Publication:
United States
Language:
English

Citation Formats

Valdez, Carlos A., Lau, Edmond Y., and Mayer, Brian P. Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds. United States: N. p., 2020. Web.
Valdez, Carlos A., Lau, Edmond Y., & Mayer, Brian P. Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds. United States.
Valdez, Carlos A., Lau, Edmond Y., and Mayer, Brian P. Tue . "Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds". United States. https://www.osti.gov/servlets/purl/1735042.
@article{osti_1735042,
title = {Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds},
author = {Valdez, Carlos A. and Lau, Edmond Y. and Mayer, Brian P.},
abstractNote = {Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals. Advantageously, the catalytic homopiperazine-based ligand-metal complexes are formed using inexpensive, readily-available precursor materials, and may be utilized to neutralize toxins without relying on damaging caustic reactants or environmentally unfriendly organic solvents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {7}
}

Works referenced in this record:

Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same
patent, January 2019


Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds
patent, October 2018