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Title: Aqueous carrier waveguide in a flow cytometer

Abstract

The liquid of a flow cytometer itself acts as an optical waveguide, thus transmitting the light to an optical filter/detector combination. This alternative apparatus and method for detecting scattered light in a flow cytometer is provided by a device which views and detects the light trapped within the optical waveguide formed by the flow stream. A fiber optic or other light collecting device is positioned within the flow stream. This provides enormous advantages over the standard light collection technique which uses a microscope objective. The signal-to-noise ratio is greatly increased over that for right-angle-scattered light collected by a microscope objective, and the alignment requirements are simplified. 6 figs.

Inventors:
; ;
Issue Date:
Research Org.:
University of California
OSTI Identifier:
170469
Patent Number(s):
5,475,487
Application Number:
PAN: 8-230,077
Assignee:
Univ. of California, Oakland, CA (United States)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 12 Dec 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; CELL FLOW SYSTEMS; LIGHT SCATTERING; OPTICAL EQUIPMENT; DESIGN; FIBER OPTICS

Citation Formats

Mariella, Jr, R P, Engh, G van den, and Northrup, M A. Aqueous carrier waveguide in a flow cytometer. United States: N. p., 1995. Web.
Mariella, Jr, R P, Engh, G van den, & Northrup, M A. Aqueous carrier waveguide in a flow cytometer. United States.
Mariella, Jr, R P, Engh, G van den, and Northrup, M A. Tue . "Aqueous carrier waveguide in a flow cytometer". United States.
@article{osti_170469,
title = {Aqueous carrier waveguide in a flow cytometer},
author = {Mariella, Jr, R P and Engh, G van den and Northrup, M A},
abstractNote = {The liquid of a flow cytometer itself acts as an optical waveguide, thus transmitting the light to an optical filter/detector combination. This alternative apparatus and method for detecting scattered light in a flow cytometer is provided by a device which views and detects the light trapped within the optical waveguide formed by the flow stream. A fiber optic or other light collecting device is positioned within the flow stream. This provides enormous advantages over the standard light collection technique which uses a microscope objective. The signal-to-noise ratio is greatly increased over that for right-angle-scattered light collected by a microscope objective, and the alignment requirements are simplified. 6 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1995},
month = {12}
}