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Title: Methods for stabilizing biological and soft materials for atom probe tomography

Abstract

Techniques are disclosed for stabilizing soft specimen traditionally considered too fragile for APT instruments. These specimens include biological samples, polymers and other fragile materials. For this purpose, a protective structure is disclosed that surrounds the sides of the specimen by supporting walls while only exposing the very end or terminus of the specimen to the electrostatic field of the APT instrument. The protective structure may take the form of a nanoscale conical grinder which continually machines the specimen to regenerate the terminus of the specimen in-situ. Alternately, the protective structure may take the form of a nanopipette in which the specimen is first frozen before undergoing field evaporation together with the tip of the nanopipette. Heretofore only routinely possible for rigid and hard materials, the design thus extends APT analysis to produce three-dimensional atomic-scale maps of soft specimens.

Inventors:
Issue Date:
Research Org.:
Hirsch Scientific, Pacifica, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1651021
Patent Number(s):
10684308
Application Number:
16/212,494
Assignee:
Hirsch, Gregory, Pacifica, CA (United States)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01Q - SCANNING-PROBE TECHNIQUES OR APPARATUS
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
SC0018599
Resource Type:
Patent
Resource Relation:
Patent File Date: 12/06/2018
Country of Publication:
United States
Language:
English

Citation Formats

Hirsch, Gregory. Methods for stabilizing biological and soft materials for atom probe tomography. United States: N. p., 2020. Web.
Hirsch, Gregory. Methods for stabilizing biological and soft materials for atom probe tomography. United States.
Hirsch, Gregory. Tue . "Methods for stabilizing biological and soft materials for atom probe tomography". United States. https://www.osti.gov/servlets/purl/1651021.
@article{osti_1651021,
title = {Methods for stabilizing biological and soft materials for atom probe tomography},
author = {Hirsch, Gregory},
abstractNote = {Techniques are disclosed for stabilizing soft specimen traditionally considered too fragile for APT instruments. These specimens include biological samples, polymers and other fragile materials. For this purpose, a protective structure is disclosed that surrounds the sides of the specimen by supporting walls while only exposing the very end or terminus of the specimen to the electrostatic field of the APT instrument. The protective structure may take the form of a nanoscale conical grinder which continually machines the specimen to regenerate the terminus of the specimen in-situ. Alternately, the protective structure may take the form of a nanopipette in which the specimen is first frozen before undergoing field evaporation together with the tip of the nanopipette. Heretofore only routinely possible for rigid and hard materials, the design thus extends APT analysis to produce three-dimensional atomic-scale maps of soft specimens.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {6}
}

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Works referenced in this record:

Multiplexed nanoscale electrochemical sensors for multi-analyte detection
patent, November 2014


Method for producing electron emitting element
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Production and manipulation of charged particles
patent, October 1992


Multiple-electrode and metal-coated probes
patent, April 2014