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Title: Methods related to a structure of high-affinity human PD-1/PD-L2 complex

Abstract

Variants of human PD-1 comprising one or more of amino acid substitutions in residues corresponding to N74, T76 and A132 of SEQ ID NO:1 are described. Also described are structures, obtained using X-ray crystallography, of the human PD-1/PD-L2 complex and mutant PD-1 variants. The structures of human PD-1 described in the present disclosure are useful in drug discovery, including small-molecule drug discovery. Accordingly, methods of using the structures in drug discovery are also described.

Inventors:
;
Issue Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1651020
Patent Number(s):
10684287
Application Number:
16/786,409
Assignee:
Chan Zuckerberg Biohub, Inc. (San Francisco, CA); The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)
Patent Classifications (CPCs):
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16C - COMPUTATIONAL CHEMISTRY
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC02-76SF00515
Resource Type:
Patent
Resource Relation:
Patent File Date: 02/10/2020
Country of Publication:
United States
Language:
English

Citation Formats

Tang, Shaogeng, and Kim, Peter S. Methods related to a structure of high-affinity human PD-1/PD-L2 complex. United States: N. p., 2020. Web.
Tang, Shaogeng, & Kim, Peter S. Methods related to a structure of high-affinity human PD-1/PD-L2 complex. United States.
Tang, Shaogeng, and Kim, Peter S. Tue . "Methods related to a structure of high-affinity human PD-1/PD-L2 complex". United States. https://www.osti.gov/servlets/purl/1651020.
@article{osti_1651020,
title = {Methods related to a structure of high-affinity human PD-1/PD-L2 complex},
author = {Tang, Shaogeng and Kim, Peter S.},
abstractNote = {Variants of human PD-1 comprising one or more of amino acid substitutions in residues corresponding to N74, T76 and A132 of SEQ ID NO:1 are described. Also described are structures, obtained using X-ray crystallography, of the human PD-1/PD-L2 complex and mutant PD-1 variants. The structures of human PD-1 described in the present disclosure are useful in drug discovery, including small-molecule drug discovery. Accordingly, methods of using the structures in drug discovery are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {6}
}

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