Methods related to a structure of high-affinity human PD-1/PD-L2 complex
Abstract
Variants of human PD-1 comprising one or more of amino acid substitutions in residues corresponding to N74, T76 and A132 of SEQ ID NO:1 are described. Also described are structures, obtained using X-ray crystallography, of the human PD-1/PD-L2 complex and mutant PD-1 variants. The structures of human PD-1 described in the present disclosure are useful in drug discovery, including small-molecule drug discovery. Accordingly, methods of using the structures in drug discovery are also described.
- Inventors:
- Issue Date:
- Research Org.:
- SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1651020
- Patent Number(s):
- 10684287
- Application Number:
- 16/786,409
- Assignee:
- Chan Zuckerberg Biohub, Inc. (San Francisco, CA); The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16C - COMPUTATIONAL CHEMISTRY
- DOE Contract Number:
- AC02-76SF00515
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 02/10/2020
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Tang, Shaogeng, and Kim, Peter S. Methods related to a structure of high-affinity human PD-1/PD-L2 complex. United States: N. p., 2020.
Web.
Tang, Shaogeng, & Kim, Peter S. Methods related to a structure of high-affinity human PD-1/PD-L2 complex. United States.
Tang, Shaogeng, and Kim, Peter S. Tue .
"Methods related to a structure of high-affinity human PD-1/PD-L2 complex". United States. https://www.osti.gov/servlets/purl/1651020.
@article{osti_1651020,
title = {Methods related to a structure of high-affinity human PD-1/PD-L2 complex},
author = {Tang, Shaogeng and Kim, Peter S.},
abstractNote = {Variants of human PD-1 comprising one or more of amino acid substitutions in residues corresponding to N74, T76 and A132 of SEQ ID NO:1 are described. Also described are structures, obtained using X-ray crystallography, of the human PD-1/PD-L2 complex and mutant PD-1 variants. The structures of human PD-1 described in the present disclosure are useful in drug discovery, including small-molecule drug discovery. Accordingly, methods of using the structures in drug discovery are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {6}
}
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