Ecteinamycin, compositions and uses thereof
Abstract
An isolated or synthesized compound of Formula I and salts thereof are provided. A compound isolated from Actinomadura and having a chemical formula of C38H60O12 is also provided. Compositions including the compounds and methods of using the compounds to treat bacterial infections including gram positive infections such as C. difficile are also disclosed.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1650932
- Patent Number(s):
- 10660874
- Application Number:
- 15/522,713
- Assignee:
- Wisconsin Alumni Research Foundation (Madison, WI)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FC02-07ER64494
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 10/28/2015
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Bugni, Timothy Scott, Wyche, Thomas Philip, Braun, Douglas R., Piotrowski, Jeffrey S., and Safdar, Nasia. Ecteinamycin, compositions and uses thereof. United States: N. p., 2020.
Web.
Bugni, Timothy Scott, Wyche, Thomas Philip, Braun, Douglas R., Piotrowski, Jeffrey S., & Safdar, Nasia. Ecteinamycin, compositions and uses thereof. United States.
Bugni, Timothy Scott, Wyche, Thomas Philip, Braun, Douglas R., Piotrowski, Jeffrey S., and Safdar, Nasia. Tue .
"Ecteinamycin, compositions and uses thereof". United States. https://www.osti.gov/servlets/purl/1650932.
@article{osti_1650932,
title = {Ecteinamycin, compositions and uses thereof},
author = {Bugni, Timothy Scott and Wyche, Thomas Philip and Braun, Douglas R. and Piotrowski, Jeffrey S. and Safdar, Nasia},
abstractNote = {An isolated or synthesized compound of Formula I and salts thereof are provided. A compound isolated from Actinomadura and having a chemical formula of C38H60O12 is also provided. Compositions including the compounds and methods of using the compounds to treat bacterial infections including gram positive infections such as C. difficile are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {5}
}
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Works referenced in this record:
Process for producing antibiotic X-14868A
patent, October 1983
- Labeda, David P.; Martin, John H. E. J.; Goodman, Joseph J.
- US Patent Document 4,407,946