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Title: Ecteinamycin, compositions and uses thereof

Abstract

An isolated or synthesized compound of Formula I and salts thereof are provided. A compound isolated from Actinomadura and having a chemical formula of C38H60O12 is also provided. Compositions including the compounds and methods of using the compounds to treat bacterial infections including gram positive infections such as C. difficile are also disclosed.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Univ. of Wisconsin, Madison, WI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1650932
Patent Number(s):
10660874
Application Number:
15/522,713
Assignee:
Wisconsin Alumni Research Foundation (Madison, WI)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FC02-07ER64494
Resource Type:
Patent
Resource Relation:
Patent File Date: 10/28/2015
Country of Publication:
United States
Language:
English

Citation Formats

Bugni, Timothy Scott, Wyche, Thomas Philip, Braun, Douglas R., Piotrowski, Jeffrey S., and Safdar, Nasia. Ecteinamycin, compositions and uses thereof. United States: N. p., 2020. Web.
Bugni, Timothy Scott, Wyche, Thomas Philip, Braun, Douglas R., Piotrowski, Jeffrey S., & Safdar, Nasia. Ecteinamycin, compositions and uses thereof. United States.
Bugni, Timothy Scott, Wyche, Thomas Philip, Braun, Douglas R., Piotrowski, Jeffrey S., and Safdar, Nasia. Tue . "Ecteinamycin, compositions and uses thereof". United States. https://www.osti.gov/servlets/purl/1650932.
@article{osti_1650932,
title = {Ecteinamycin, compositions and uses thereof},
author = {Bugni, Timothy Scott and Wyche, Thomas Philip and Braun, Douglas R. and Piotrowski, Jeffrey S. and Safdar, Nasia},
abstractNote = {An isolated or synthesized compound of Formula I and salts thereof are provided. A compound isolated from Actinomadura and having a chemical formula of C38H60O12 is also provided. Compositions including the compounds and methods of using the compounds to treat bacterial infections including gram positive infections such as C. difficile are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {5}
}

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Works referenced in this record:

Process for producing antibiotic X-14868A
patent, October 1983