HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations
Abstract
The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
- Inventors:
- Issue Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1650887
- Patent Number(s):
- 10647748
- Application Number:
- 16/176,200
- Assignee:
- The Scripps Research Institute (La Jolla, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC02-06CH11357
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 10/31/2018
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Kong, Leopold, Wilson, Ian A., De Val, Natalia, Ward, Andrew B., Burton, Dennis R., He, Linling, and Zhu, Jiang. HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations. United States: N. p., 2020.
Web.
Kong, Leopold, Wilson, Ian A., De Val, Natalia, Ward, Andrew B., Burton, Dennis R., He, Linling, & Zhu, Jiang. HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations. United States.
Kong, Leopold, Wilson, Ian A., De Val, Natalia, Ward, Andrew B., Burton, Dennis R., He, Linling, and Zhu, Jiang. Tue .
"HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations". United States. https://www.osti.gov/servlets/purl/1650887.
@article{osti_1650887,
title = {HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations},
author = {Kong, Leopold and Wilson, Ian A. and De Val, Natalia and Ward, Andrew B. and Burton, Dennis R. and He, Linling and Zhu, Jiang},
abstractNote = {The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 12 00:00:00 EDT 2020},
month = {Tue May 12 00:00:00 EDT 2020}
}
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Works referenced in this record:
Novel HIV-1 Envelope Glycoprotein
patent-application, July 2014
- Caulfield, Michael; Cupo, Albert; Dean, HAnsi
- US Patent Application 14/072209; 20140212458