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Title: HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations

Abstract

The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1650887
Patent Number(s):
10647748
Application Number:
16/176,200
Assignee:
The Scripps Research Institute (La Jolla, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 10/31/2018
Country of Publication:
United States
Language:
English

Citation Formats

Kong, Leopold, Wilson, Ian A., De Val, Natalia, Ward, Andrew B., Burton, Dennis R., He, Linling, and Zhu, Jiang. HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations. United States: N. p., 2020. Web.
Kong, Leopold, Wilson, Ian A., De Val, Natalia, Ward, Andrew B., Burton, Dennis R., He, Linling, & Zhu, Jiang. HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations. United States.
Kong, Leopold, Wilson, Ian A., De Val, Natalia, Ward, Andrew B., Burton, Dennis R., He, Linling, and Zhu, Jiang. Tue . "HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations". United States. https://www.osti.gov/servlets/purl/1650887.
@article{osti_1650887,
title = {HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations},
author = {Kong, Leopold and Wilson, Ian A. and De Val, Natalia and Ward, Andrew B. and Burton, Dennis R. and He, Linling and Zhu, Jiang},
abstractNote = {The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {5}
}

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