Selective high-affinity polydentate ligands and methods of making such
Abstract
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1650872
- Patent Number(s):
- 10646502
- Application Number:
- 15/703,848
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 09/13/2017
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
DeNardo, Sally J., Denardo, Gerald L., and Balhorn, Rodney L. Selective high-affinity polydentate ligands and methods of making such. United States: N. p., 2020.
Web.
DeNardo, Sally J., Denardo, Gerald L., & Balhorn, Rodney L. Selective high-affinity polydentate ligands and methods of making such. United States.
DeNardo, Sally J., Denardo, Gerald L., and Balhorn, Rodney L. Tue .
"Selective high-affinity polydentate ligands and methods of making such". United States. https://www.osti.gov/servlets/purl/1650872.
@article{osti_1650872,
title = {Selective high-affinity polydentate ligands and methods of making such},
author = {DeNardo, Sally J. and Denardo, Gerald L. and Balhorn, Rodney L.},
abstractNote = {This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {5}
}
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