Selective high-affinity polydentate ligands and methods of making such

DeNardo, Sally J.; Denardo, Gerald L.; Balhorn, Rodney L.

Title: Selective high-affinity polydentate ligands and methods of making such

Abstract

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

Inventors:: DeNardo, Sally J.; Denardo, Gerald L.; Balhorn, Rodney L.

Issue Date:: 2020-05-12

Research Org.:: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1650872

Patent Number(s):: 10646502

Application Number:: 15/703,848

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/675 - having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K47/545 - {Heterocyclic compounds
A61K47/55 - the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K47/60 - the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K47/645 - {Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00 - Antineoplastic agents
A61P35/02 - specific for leukemia
A61P35/04 - specific for metastasis

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DOE Contract Number:: AC52-07NA27344

Resource Type:: Patent

Resource Relation:: Patent File Date: 09/13/2017

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    DeNardo, Sally J., Denardo, Gerald L., and Balhorn, Rodney L. Selective high-affinity polydentate ligands and methods of making such.  United States: N. p., 2020. 
        Web.

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                    DeNardo, Sally J., Denardo, Gerald L., & Balhorn, Rodney L. Selective high-affinity polydentate ligands and methods of making such.  United States.

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                    DeNardo, Sally J., Denardo, Gerald L., and Balhorn, Rodney L. Tue .  
        "Selective high-affinity polydentate ligands and methods of making such".  United States.  https://www.osti.gov/servlets/purl/1650872.

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@article{osti_1650872,

  title        = {Selective high-affinity polydentate ligands and methods of making such},

  author       = {DeNardo, Sally J. and Denardo, Gerald L. and Balhorn, Rodney L.},

  abstractNote = {This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2020},

  month        = {5}

}

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