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Title: Selective high-affinity polydentate ligands and methods of making such

Abstract

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1650872
Patent Number(s):
10646502
Application Number:
15/703,848
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 09/13/2017
Country of Publication:
United States
Language:
English

Citation Formats

DeNardo, Sally J., Denardo, Gerald L., and Balhorn, Rodney L.. Selective high-affinity polydentate ligands and methods of making such. United States: N. p., 2020. Web.
DeNardo, Sally J., Denardo, Gerald L., & Balhorn, Rodney L.. Selective high-affinity polydentate ligands and methods of making such. United States.
DeNardo, Sally J., Denardo, Gerald L., and Balhorn, Rodney L.. Tue . "Selective high-affinity polydentate ligands and methods of making such". United States. https://www.osti.gov/servlets/purl/1650872.
@article{osti_1650872,
title = {Selective high-affinity polydentate ligands and methods of making such},
author = {DeNardo, Sally J. and Denardo, Gerald L. and Balhorn, Rodney L.},
abstractNote = {This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {5}
}

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Selective high-affinity polydentate ligands and methods of making such
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