Selective high-affinity polydentate ligands and methods of making such
Abstract
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1650872
- Patent Number(s):
- 10646502
- Application Number:
- 15/703,848
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 09/13/2017
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
DeNardo, Sally J., Denardo, Gerald L., and Balhorn, Rodney L. Selective high-affinity polydentate ligands and methods of making such. United States: N. p., 2020.
Web.
DeNardo, Sally J., Denardo, Gerald L., & Balhorn, Rodney L. Selective high-affinity polydentate ligands and methods of making such. United States.
DeNardo, Sally J., Denardo, Gerald L., and Balhorn, Rodney L. Tue .
"Selective high-affinity polydentate ligands and methods of making such". United States. https://www.osti.gov/servlets/purl/1650872.
@article{osti_1650872,
title = {Selective high-affinity polydentate ligands and methods of making such},
author = {DeNardo, Sally J. and Denardo, Gerald L. and Balhorn, Rodney L.},
abstractNote = {This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {5}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Bispecific antibodies for retargeting anticancer cytotoxic lymphocytes
patent-application, May 2001
- Weiner, George J.; Rokhlin, Oska W.; Cohen, Michael B.
- US Patent Application 09/757336; 20010001310
Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
patent, July 1991
- Abrams, Paul G.; Schroff, Robert W.; Morgan, Jr., Alton C.
- US Patent Document 5,034,223
Structure-based hepatitis c virus drug design
patent-application, September 2003
- Bolognesi, Martino; Grandi, Guido
- US Patent Application 10/312490; 20030176662
Bispecific antibodies that bind to vegf receptors
patent-application, December 2004
- Zhu, Zhenping
- US Patent Application 10/482630; 20040242851
Antigenic epitopes with LYM-1 reactivity and uses thereof
patent, April 2001
- Rose, Larry M.; Meares, Claude F.; O'Donnell, Robert
- US Patent Document 6,217,871
Radioimmunotherapy of lymphoma using anti-CD20
patent, January 1997
- Kaminski, Mark S.; Butchko, Gregory M.; Glenn, Stephan D.
- US Patent Document 5,595,721
Bispecific antibodies, methods of production and uses thereof
patent, September 1999
- Ring, David B.; Shi, Tian
- US Patent Document 5,959,084
Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
patent, November 1982
- Goldenberg, Milton D.
- US Patent Document 4,361,544
Bispecific antibodies
patent-application, January 2006
- Lee, Randall J.; Larrick, James; Lum, Lawrence G.
- US Patent Application 11/170716; 20060018897
Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
patent, May 1982
- Goldenberg, Milton D.
- US Patent Document 4,331,647
Bispecific antibodies, methods of production and use thereof
patent, August 2000
- Ring, David B.; Shi, Tian
- US Patent Document 6,106,833
Selective high affinity polydentate ligands and methods of making such
patent-application, April 2006
- DeNardo, Sally; DeNardo, Gerald; Balhorn, Rodney
- US Patent Application 11/055181; 20060084115
Bispecific antibodies
patent-application, June 2005
- Kufer, Peter; Berry, Meera; Baeuerle, Patrick
- US Patent Application 10/743697; 20050136050
Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2
patent-application, October 2002
- Lynch, David H.
- US Patent Application 09/839632; 20020155109
Destruction of contaminating tumor cells in stem cell transplants using bispecific antibodies
patent, November 1999
- Lindhofer, Horst; Menzel, Helge; Kolb, Hans-Jochem
- US Patent Document 5,985,276
Bispecific antibodies for selective immune regulation and for selective immune cell binding
patent, February 1997
- Wong, Johnson; Colvin, Robert
- US Patent Document 5,601,819
Tumor localization and therapy with labeled antibodies to cell surface antigens
patent, April 1984
- Goldenberg, Milton D.
- US Patent Document 4,444,744
Process for the production of hetero-bispecific antibodies
patent, May 2000
- Lenz, Helmut; Weidle, Ulrich
- US Patent Document 6,060,285
Bispecific antibodies for inducing apoptosis of tumor and diseased cells
patent-application, April 2005
- Hsing-Chang, Chien; Goldenberg, David M.; Hansen, Hans J.
- US Patent Application 10/913509; 20050079184
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
patent, January 2000
- Ledbetter, Jeffrey A.; Gilliland, Lisa Kim
- US Patent Document 6,010,902
Destruction of contaminating tumor cells in stem cell transplants using bispecific antibodies
patent, April 2001
- Lindhofer, Horst; Menzel, Helge; Kolb, Hans-Jochem
- US Patent Document 6,210,668
Method of enhancing the biodistribution of antibody for localization in lesions
patent, May 1990
- Beatty, John; Beatty, Barbara G.; Duda, Rosemary B.
- US Patent Document 4,921,690
Use of bispecific antibodies to regulate immune responses
patent-application, April 2003
- Bigler, Michael Eric; Cherwinski, Holly Marie; Phillips, Joseph H.
- US Patent Application 10/270084; 20030077282
Selective high-affinity polydentate ligands and methods of making such
patent, September 2013
- DeNardo, Sally J.; DeNardo, Gerald L.; Balhorn, Rodney L.
- US Patent Document 8,536,133