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Title: Synthetic methylotrophs

Abstract

The present invention provides a non-naturally occurring microbe capable of growing in a medium comprising methanol, comprising a heterologous polynucleotide encoding a heterologous methanol dehydrogenase (MDH) derived from a Corynebacterium organism (Cor), wherein the MDH is expressed in the microbe, and wherein the MDH exhibits a Km of no more than 3 mM for methanol. Also provided are uses of the non-naturally occurring microbe for oxidizing methanol and producing a metabolite as well as the preparation of the non-naturally occurring microbe.

Inventors:
; ;
Issue Date:
Research Org.:
Univ. of Delaware, Newark, DE (United States)
Sponsoring Org.:
USDOE Advanced Research Projects Agency - Energy (ARPA-E)
OSTI Identifier:
1650848
Patent Number(s):
10640746
Application Number:
16/070,318
Assignee:
University of Delaware (Newark, DE)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12R - PROCESSES USING MICROORGANISMS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AR0000432
Resource Type:
Patent
Resource Relation:
Patent File Date: 01/13/2017
Country of Publication:
United States
Language:
English

Citation Formats

Papoutsakis, Eleftherios T., Whitaker, William Brian, and Bennett, Robert Kyle. Synthetic methylotrophs. United States: N. p., 2020. Web.
Papoutsakis, Eleftherios T., Whitaker, William Brian, & Bennett, Robert Kyle. Synthetic methylotrophs. United States.
Papoutsakis, Eleftherios T., Whitaker, William Brian, and Bennett, Robert Kyle. Tue . "Synthetic methylotrophs". United States. https://www.osti.gov/servlets/purl/1650848.
@article{osti_1650848,
title = {Synthetic methylotrophs},
author = {Papoutsakis, Eleftherios T. and Whitaker, William Brian and Bennett, Robert Kyle},
abstractNote = {The present invention provides a non-naturally occurring microbe capable of growing in a medium comprising methanol, comprising a heterologous polynucleotide encoding a heterologous methanol dehydrogenase (MDH) derived from a Corynebacterium organism (Cor), wherein the MDH is expressed in the microbe, and wherein the MDH exhibits a Km of no more than 3 mM for methanol. Also provided are uses of the non-naturally occurring microbe for oxidizing methanol and producing a metabolite as well as the preparation of the non-naturally occurring microbe.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {5}
}

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