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Title: Bio-assessment device and method of making the device

Abstract

Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1650824
Patent Number(s):
10634665
Application Number:
15/513,949
Assignee:
Triad National Security, LLC (Los Alamos, NM); Vanderbilt University (Nashville, TN)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 09/24/2015
Country of Publication:
United States
Language:
English

Citation Formats

Iyer, Rashi, Huang, Jen-Huang, Nath, Pulak, Harris, Jennifer, and Wikswo, Jr., John P.. Bio-assessment device and method of making the device. United States: N. p., 2020. Web.
Iyer, Rashi, Huang, Jen-Huang, Nath, Pulak, Harris, Jennifer, & Wikswo, Jr., John P.. Bio-assessment device and method of making the device. United States.
Iyer, Rashi, Huang, Jen-Huang, Nath, Pulak, Harris, Jennifer, and Wikswo, Jr., John P.. Tue . "Bio-assessment device and method of making the device". United States. https://www.osti.gov/servlets/purl/1650824.
@article{osti_1650824,
title = {Bio-assessment device and method of making the device},
author = {Iyer, Rashi and Huang, Jen-Huang and Nath, Pulak and Harris, Jennifer and Wikswo, Jr., John P.},
abstractNote = {Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {4}
}

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Works referenced in this record:

Vascularized perfused microtissue/micro-organ arrays
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Micro-organ device
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Chemically defined medium for cultured mammalian cells
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