Title: Bio-assessment device and method of making the device

Abstract

Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.

Inventors:

Iyer, Rashi; Huang, Jen-Huang; Nath, Pulak; Harris, Jennifer; Wikswo, Jr., John P.

Issue Date:

Tue Apr 28 00:00:00 EDT 2020

Research Org.:

Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1650824

Patent Number(s):

10634665

Application Number:

15/513,949

Assignee:

Triad National Security, LLC (Los Alamos, NM); Vanderbilt University (Nashville, TN)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L2200/027 - for microfluidic devices
B01L2300/0627 - Sensor or part of a sensor is integrated
B01L2300/0681 - Filter
B01L2300/0832 - cylindrical, tube shaped
B01L2300/0887 - Laminated structure
B01L2300/123 - Flexible
B01L2400/0481 - squeezing of channels or chambers
B01L2400/0633 - with moving parts
B01L3/5027 - {by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
B01L3/502707 - {characterised by the manufacture of the container or its components
B01L3/502715 - {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
B01L3/50273 - {characterised by the means or forces applied to move the fluids
B01L3/502738 - {characterised by integrated valves

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N5/06 - {Animal cells or tissues
C12N5/067 - {Hepatocytes}

F - MECHANICAL ENGINEERING F16 - ENGINEERING ELEMENTS AND UNITS F16K - VALVES

F16K7/045 - {by electric or magnetic means}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/5008 - {for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics}
G01N33/5014 - {for testing toxicity}
G01N33/5064 - {Endothelial cells}
G01N33/5082 - {Supracellular entities, e.g. tissue, organisms}

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DOE Contract Number:  

AC52-06NA25396

Resource Type:

Patent

Resource Relation:

Patent File Date: 09/24/2015

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY