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Title: Fluid delivery manifolds and microfluidic systems

Abstract

Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1650796
Patent Number(s):
10627366
Application Number:
15/407,088
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 01/16/2017
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Renzi, Ronald F., Sommer, Gregory J., Singh, Anup K., Hatch, Anson V., Claudnic, Mark R., Wang, Ying-Chih, and Van de Vreugde, James L.. Fluid delivery manifolds and microfluidic systems. United States: N. p., 2020. Web.
Renzi, Ronald F., Sommer, Gregory J., Singh, Anup K., Hatch, Anson V., Claudnic, Mark R., Wang, Ying-Chih, & Van de Vreugde, James L.. Fluid delivery manifolds and microfluidic systems. United States.
Renzi, Ronald F., Sommer, Gregory J., Singh, Anup K., Hatch, Anson V., Claudnic, Mark R., Wang, Ying-Chih, and Van de Vreugde, James L.. Tue . "Fluid delivery manifolds and microfluidic systems". United States. https://www.osti.gov/servlets/purl/1650796.
@article{osti_1650796,
title = {Fluid delivery manifolds and microfluidic systems},
author = {Renzi, Ronald F. and Sommer, Gregory J. and Singh, Anup K. and Hatch, Anson V. and Claudnic, Mark R. and Wang, Ying-Chih and Van de Vreugde, James L.},
abstractNote = {Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {4}
}

Works referenced in this record:

Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
patent-application, February 2018


Microfluidic Platform for Synthetic Biology Applications
patent-application, October 2012


Portable medical diagnosis instrument
patent, November 2017


Compact radiation detector
patent, June 2018


Multiplexed microfluidic approach for nucleic acid enrichment
patent, April 2016


Method and Device for Tracking and Manipulation of Droplets
patent-application, December 2017


Methods, microfluidic devices, and systems for detection of an active enzymatic agent
patent, October 2014


Multiplexed Screening of Enzyme Activities Using Nanostructure-initiator Mass Spectrometry
patent-application, September 2012


Edge compression manifold apparatus
patent, December 2004


Devices, systems, and methods for detecting nucleic acids using sedimentation
patent, August 2019


High temperature flow-through device for rapid solubilization and analysis
patent, April 2013


Ion Chamber Based Neutron Detectors
patent-application, January 2013


Capillary interconnect device
patent, November 2013


Quantitative detection of pathogens in centrifugal microfluidic disks
patent, February 2018


Method for forming polymerized microfluidic devices
patent, November 2011


System for concentrating and analyzing particles suspended in a fluid
patent, April 2011


Virtual environment tactile system
patent, December 1996


Microfluidic Structures and Methods for Integrating a Functional Component Into a Microfluidic Device
patent-application, July 2005


Method for voltage-gated protein fractionation
patent, April 2012


Method for enhanced control of welding processes
patent, July 2000


Dialysis membrane for separation on microchips
patent, July 2010


High temperature flow-through device for rapid solubilization and analysis
patent, September 2009


Portable apparatus for separating sample and detecting target analytes
patent, November 2008


Systems, Devices, and Methods For Agglutination Assays Using Sedimentation
patent-application, March 2016


Systems, devices, and methods for agglutination assays using sedimentation
patent, January 2016


Microfluidics Prototyping Platform and Components
patent-application, August 2006


Microelectroporation Device for Genomic Screening
patent-application, January 2012


Apparatus and method for concentrating and filtering particles suspended in a fluid
patent, May 2009


Multidimensional electrophoresis and methods of making and using thereof
patent-application, June 2004


Fluid Delivery Manifolds and Microfluidic Systems
patent-application, May 2017


System and Method for Detecting Components of a Mixture Including a Valving Scheme for Competition Assays
patent-application, September 2017


Optical Detector System
patent-application, February 2005


Microfluidic Platform for Multiplexed Detection in Single Cells and Methods Thereof
patent-application, July 2018


Toxin Activity Assays, Devices, Methods And Systems Therefor
patent-application, June 2016


High pressure capillary connector
patent, August 2005


Edge compression manifold apparatus
patent, February 2007


Microliter scale solid phase extraction devices
patent-application, July 2006


Methods for integrating a functional component into a microfluidic device
patent, August 2014


Electrokinetic concentration of charged molecules
patent, August 2002


Microelectroporation device for genomic screening
patent, September 2014


Microfluidic Devices and Methods Including Porous Polymer Monoliths
patent-application, June 2014


Method and apparatus for gel electrophoretic immunoassay
patent-application, August 2006


Microfluidic hubs, systems, and methods for interface fluidic modules
patent, January 2015


Dielectrokinetic chromatography devices
patent, December 2014


System for Gel Electrophoretic Immunoassay
patent-application, August 2006


System for particle concentration and detection
patent, March 2013


Toxin Activity Assays, Devices, Methods and Systems Therefor
patent-application, June 2019


Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
patent, November 2015


Microfluidic devices and methods for integrated flow cytometry
patent, August 2011


Fluid delivery manifolds and microfluidic systems
patent, February 2017


Dielectrophoretic Systems Without Embedded Electrodes
patent-application, February 2004


Dielectrokinetic chromatography and devices thereof
patent, April 2014


Sensor cartridges
patent, September 2000


Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
patent, February 2015


Modular optical detector system
patent, February 2006


Method for dialysis on microchips using thin porous polymer membrane
patent, May 2009


Devices, systems, and methods for detecting nucleic acids using sedimentation
patent-application, March 2018


Methods, Microfluidic Devices, and Systems for Detection of an Active Enzymatic Agent
patent-application, February 2015


Microchannel gel electrophoretic separation systems and methods for preparing and using
patent, February 2015


Toxin activity assays, devices, methods and systems therefor
patent, April 2016


Devices, systems, and methods for microscale isoelectric fractionation
patent, August 2016


Dielectrophoretic systems without embedded electrodes
patent, March 2006


Particle sorter comprising a fluid displacer in a closed-loop fluid circuit
patent, April 2012


System for Concentrating and Analyzing Particles Suspended in a Fluid
patent-application, January 2009


Devices, Systems, and Methods for Detecting Nucleic Acids Using Sedimentation
patent-application, July 2019


Devices, systems, and methods for microscale isoelectric fractionation
patent, April 2015


Microfluidic devices and methods including porous polymer monoliths
patent, April 2014


Compact ion chamber based neutron detector
patent, October 2015


Portable modular detection system
patent, October 2009


Method for forming polymerized microfluidic devices
patent, March 2013


Microchannel gel electrophoretic separation systems and methods for preparing and using
patent, September 2013


Dialysis on microchips using thin porous polymer membranes
patent, September 2007


Devices, systems, and methods for detecting nucleic acids using sedimentation
patent, October 2017


Devices, Systems, and Methods for Conducting Assays with Improved Sensitivity Using Sedimentation
patent-application, June 2014


Viral Identification by Generation and Detection of Protein Signatures
patent-application, January 2005


Preconcentration and separation of analytes in microchannels
patent, November 2010


Micromanifold assembly
patent, June 2009


Method and apparatus for calibrating a particle emissions monitor
patent, July 1998


Capillary interconnect device
patent, December 2007


Ion chamber based neutron detectors
patent, December 2014


Sol-gel method for encapsulating molecules
patent, December 2002


Microvalve
patent, July 2005


Planar micromixer
patent, March 2008


Lanthanide-Chelator Combinatorial Barcoding
patent-application, December 2017


Quantitative detection of pathogens in centrifugal microfluidic disks
patent-application, February 2018


Microfluidic integrated microarrays for biological detection
patent-application, May 2005


Microfluidic platform for synthetic biology applications
patent, November 2018


Piecewise uniform conduction-like flow channels and method therefor
patent, February 2006


Devices, Systems, and Methods for Conducting Assays with Improved Sensitivity Using Sedimentation
patent-application, May 2015


Systems, devices, and methods for agglutination assays using sedimentation
patent, July 2018


Devices, systems, and methods for conducting sandwich assays using sedimentation
patent, February 2015


Dialysis on Microchips Using Thin Porous Polymer Membranes
patent-application, May 2004


Modular Microfluidic System
patent-application, November 2005


Digital Microfluidic Systems with Electrodes BUs and Methods for Droplet Manipulation
patent-application, May 2019


Portable Apparatus for Separating Sample and Detecting Target Analytes
patent-application, July 2004


High Temperature Flow-Through Device for Rapid Solubilization and Analysis
patent-application, August 2009


Multi-Analyte Analysis of Saliva Biomarkers as Predictors of Periodontal and Pre-Implant Disease
patent-application, August 2010


Fluid Delivery Manifolds and Microfluidic Systems
patent-application, April 2012


Fluid injection microvalve
patent, November 2005


Digital Microfluidic Systems and Methods for Droplet Manipulation
patent-application, May 2019


Microchannel Gel Electrophoretic Separation Systems and Methods for Preparing and Using
patent-application, December 2013


Evaporation management in digital microfluidic devices
patent-application, June 2018


Multidimensional bioseparation with modular microfluidics
patent, August 2013


Microfluidic devices and methods including porous polymer monoliths
patent, December 2015


Micromanifold assembly
patent, April 2012


Microfluidic Devices, Systems, And Methods For Quantifying Particles Using Centrifugal Force
patent-application, December 2015