Title: Methods for treating diseases related to the wnt pathway

Abstract

The present invention relates to methods for treating a disease, in which the disease arises from dysregulation of the Wnt signaling pathway. In some instances, the disease can be treated by administering a Wnt pathway inhibitory compound. In other instances, the method optionally includes conducting a genome-wide screening to determine one or more genes resulting in a reduced disease state and then identifying the gene(s) as being involved in the Wnt signaling pathway.

Inventors:

Negrete, Oscar A.; Harmon, Brooke Nicole

Issue Date:

2020-04-21

Research Org.:

Sandia National Lab. (SNL-CA), Livermore, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1650782

Patent Number(s):

10624949

Application Number:

15/204,804

Assignee:

National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K31/136 - having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K31/407 - condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
A61K31/4439 - containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K31/475 - having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
A61K38/1709 - {from mammals}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6883 - for diseases caused by alterations of genetic material
C12Q2600/178 - miRNA, siRNA or ncRNA

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

Y02A50/30 - Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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DOE Contract Number:  

AC04-94AL85000

Resource Type:

Patent

Resource Relation:

Patent File Date: 07/07/2016

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES