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Title: Increased ethanol production by thermophilic microorganisms with deletion of individual hfs hydrogenase subunits

Abstract

Disclosed are methods for engineering bacteria, for example, Thermoanaerobacterium saccharolyticum, that convert biomass to ethanol at high yield by deleting a single gene. Deletion of subunit A or subunit B of the hfs hydrogenase, but not deletion of subunit C or subunit D, results in an increase in ethanol yield.

Inventors:
; ;
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1650762
Patent Number(s):
10619172
Application Number:
15/656,665
Assignee:
Trustees of Dartmouth College (Hanover, NH)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 07/21/2017
Country of Publication:
United States
Language:
English

Citation Formats

Eminoglu, Aysenur, Olson, Daniel G., and Lynd, Lee R.. Increased ethanol production by thermophilic microorganisms with deletion of individual hfs hydrogenase subunits. United States: N. p., 2020. Web.
Eminoglu, Aysenur, Olson, Daniel G., & Lynd, Lee R.. Increased ethanol production by thermophilic microorganisms with deletion of individual hfs hydrogenase subunits. United States.
Eminoglu, Aysenur, Olson, Daniel G., and Lynd, Lee R.. Tue . "Increased ethanol production by thermophilic microorganisms with deletion of individual hfs hydrogenase subunits". United States. https://www.osti.gov/servlets/purl/1650762.
@article{osti_1650762,
title = {Increased ethanol production by thermophilic microorganisms with deletion of individual hfs hydrogenase subunits},
author = {Eminoglu, Aysenur and Olson, Daniel G. and Lynd, Lee R.},
abstractNote = {Disclosed are methods for engineering bacteria, for example, Thermoanaerobacterium saccharolyticum, that convert biomass to ethanol at high yield by deleting a single gene. Deletion of subunit A or subunit B of the hfs hydrogenase, but not deletion of subunit C or subunit D, results in an increase in ethanol yield.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {4}
}

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