Positive modulator of bone morphogenic protein-2
Abstract
Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1650734
- Patent Number(s):
- 10611810
- Application Number:
- 12/023,801
- Assignee:
- Ferring International Center S.A. (CH)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 01/31/2008
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, and Takahashi, Kazuyuki. Positive modulator of bone morphogenic protein-2. United States: N. p., 2020.
Web.
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, & Takahashi, Kazuyuki. Positive modulator of bone morphogenic protein-2. United States.
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, and Takahashi, Kazuyuki. Tue .
"Positive modulator of bone morphogenic protein-2". United States. https://www.osti.gov/servlets/purl/1650734.
@article{osti_1650734,
title = {Positive modulator of bone morphogenic protein-2},
author = {Zamora, Paul O. and Pena, Louis A. and Lin, Xinhua and Takahashi, Kazuyuki},
abstractNote = {Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {4}
}
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