Compounds for reactivation of acetylcholinesterase and related compositions methods and systems
Abstract
Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1637828
- Patent Number(s):
- 10590498
- Application Number:
- 15/595,400
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 05/15/2017
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Valdez, Carlos A., Be, Nicholas A., Bennion, Brian, Carpenter, Tim, Enright, Heather Ann, Lightstone, Felice, Malfatti, Mike, McNerney, Margaret Windy, and Nguyen, Tuan H.. Compounds for reactivation of acetylcholinesterase and related compositions methods and systems. United States: N. p., 2020.
Web.
Valdez, Carlos A., Be, Nicholas A., Bennion, Brian, Carpenter, Tim, Enright, Heather Ann, Lightstone, Felice, Malfatti, Mike, McNerney, Margaret Windy, & Nguyen, Tuan H.. Compounds for reactivation of acetylcholinesterase and related compositions methods and systems. United States.
Valdez, Carlos A., Be, Nicholas A., Bennion, Brian, Carpenter, Tim, Enright, Heather Ann, Lightstone, Felice, Malfatti, Mike, McNerney, Margaret Windy, and Nguyen, Tuan H.. Tue .
"Compounds for reactivation of acetylcholinesterase and related compositions methods and systems". United States. https://www.osti.gov/servlets/purl/1637828.
@article{osti_1637828,
title = {Compounds for reactivation of acetylcholinesterase and related compositions methods and systems},
author = {Valdez, Carlos A. and Be, Nicholas A. and Bennion, Brian and Carpenter, Tim and Enright, Heather Ann and Lightstone, Felice and Malfatti, Mike and McNerney, Margaret Windy and Nguyen, Tuan H.},
abstractNote = {Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {3}
}
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