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Title: Compounds for reactivation of acetylcholinesterase and related compositions methods and systems

Abstract

Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.

Inventors:
; ; ; ; ; ; ; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1637828
Patent Number(s):
10590498
Application Number:
15/595,400
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 05/15/2017
Country of Publication:
United States
Language:
English

Citation Formats

Valdez, Carlos A., Be, Nicholas A., Bennion, Brian, Carpenter, Tim, Enright, Heather Ann, Lightstone, Felice, Malfatti, Mike, McNerney, Margaret Windy, and Nguyen, Tuan H.. Compounds for reactivation of acetylcholinesterase and related compositions methods and systems. United States: N. p., 2020. Web.
Valdez, Carlos A., Be, Nicholas A., Bennion, Brian, Carpenter, Tim, Enright, Heather Ann, Lightstone, Felice, Malfatti, Mike, McNerney, Margaret Windy, & Nguyen, Tuan H.. Compounds for reactivation of acetylcholinesterase and related compositions methods and systems. United States.
Valdez, Carlos A., Be, Nicholas A., Bennion, Brian, Carpenter, Tim, Enright, Heather Ann, Lightstone, Felice, Malfatti, Mike, McNerney, Margaret Windy, and Nguyen, Tuan H.. Tue . "Compounds for reactivation of acetylcholinesterase and related compositions methods and systems". United States. https://www.osti.gov/servlets/purl/1637828.
@article{osti_1637828,
title = {Compounds for reactivation of acetylcholinesterase and related compositions methods and systems},
author = {Valdez, Carlos A. and Be, Nicholas A. and Bennion, Brian and Carpenter, Tim and Enright, Heather Ann and Lightstone, Felice and Malfatti, Mike and McNerney, Margaret Windy and Nguyen, Tuan H.},
abstractNote = {Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {3}
}

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