Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination
Abstract
Provided herein are methods and compositions for the electrochemical selective radiofluorination of aromatic molecules. The resulting fluorine-18 labeled compounds are ideal radionuclides for use in Positron Emission Tomography (PET); they are also difficult to radiolabel efficiently and with high specific activity using existing approaches. For example, radiopharmaceuticals such as [F18]L-DOPA, which is indispensable in PET brain disease imaging, may be made electrochemically with high radiochemical yield and high specific activity using 18F-. The invention process described herein opens new possibilities and provides wider access to PET tracers such as 18F-L-Dopa, since 18F- is much more widely available than the 18F2, currently used for synthesis of electron rich substrates.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1637790
- Patent Number(s):
- 10597340
- Application Number:
- 14/937,649
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 11/10/2015
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
Citation Formats
Sadeghi, Saman, He, Qinggang, and Lebedev, Artem. Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination. United States: N. p., 2020.
Web.
Sadeghi, Saman, He, Qinggang, & Lebedev, Artem. Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination. United States.
Sadeghi, Saman, He, Qinggang, and Lebedev, Artem. Tue .
"Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination". United States. https://www.osti.gov/servlets/purl/1637790.
@article{osti_1637790,
title = {Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination},
author = {Sadeghi, Saman and He, Qinggang and Lebedev, Artem},
abstractNote = {Provided herein are methods and compositions for the electrochemical selective radiofluorination of aromatic molecules. The resulting fluorine-18 labeled compounds are ideal radionuclides for use in Positron Emission Tomography (PET); they are also difficult to radiolabel efficiently and with high specific activity using existing approaches. For example, radiopharmaceuticals such as [F18]L-DOPA, which is indispensable in PET brain disease imaging, may be made electrochemically with high radiochemical yield and high specific activity using 18F-. The invention process described herein opens new possibilities and provides wider access to PET tracers such as 18F-L-Dopa, since 18F- is much more widely available than the 18F2, currently used for synthesis of electron rich substrates.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {3}
}
Works referenced in this record:
Method for preparing polymers containing cyclopentanone structures
patent, August 2006
- Umemoto, Teruo
- US Patent Document 7,087,681