Systems and methods for detecting metal ion concentrations in subjects

Chang, Christopher J.; Long, Jeffrey R.; Lee, Sumin; Barin, Gokhan

Title: Systems and methods for detecting metal ion concentrations in subjects

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Abstract

A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.

Inventors:: Chang, Christopher J.; Long, Jeffrey R.; Lee, Sumin; Barin, Gokhan

Issue Date:: 2020-03-31

Research Org.:: Univ. of California, Oakland, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1637767

Patent Number(s):: 10605799

Application Number:: 15/593,117

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C22 - METALLURGY C22B - PRODUCTION AND REFINING OF METALS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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C - CHEMISTRY C22 - METALLURGY C22B - PRODUCTION AND REFINING OF METALS
C22B3/0018 - {using ethers or epoxides}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/48714 - {for determining substances foreign to the organism, e.g. drugs or heavy metals
G01N31/22 - using chemical indicators
G01N33/84 - involving inorganic compounds or pH

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J20/3042 - {Use of binding agents

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D2257/60 - Heavy metals or heavy metal compounds

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/5306 - {Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding}
G01N33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper {and including single- and multilayer analytical elements

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DOE Contract Number:: SC0001015

Resource Type:: Patent

Resource Relation:: Patent File Date: 05/11/2017

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Chang, Christopher J., Long, Jeffrey R., Lee, Sumin, and Barin, Gokhan. Systems and methods for detecting metal ion concentrations in subjects.  United States: N. p., 2020. 
        Web.

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                    Chang, Christopher J., Long, Jeffrey R., Lee, Sumin, & Barin, Gokhan. Systems and methods for detecting metal ion concentrations in subjects.  United States.

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                    Chang, Christopher J., Long, Jeffrey R., Lee, Sumin, and Barin, Gokhan. Tue .  
        "Systems and methods for detecting metal ion concentrations in subjects".  United States.  https://www.osti.gov/servlets/purl/1637767.

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@article{osti_1637767,

  title        = {Systems and methods for detecting metal ion concentrations in subjects},

  author       = {Chang, Christopher J. and Long, Jeffrey R. and Lee, Sumin and Barin, Gokhan},

  abstractNote = {A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2020},

  month        = {3}

}

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