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Title: Systems and methods for detecting metal ion concentrations in subjects

Abstract

A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.

Inventors:
; ; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1637767
Patent Number(s):
10605799
Application Number:
15/593,117
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C22 - METALLURGY C22B - PRODUCTION AND REFINING OF METALS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
SC0001015
Resource Type:
Patent
Resource Relation:
Patent File Date: 05/11/2017
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Chang, Christopher J., Long, Jeffrey R., Lee, Sumin, and Barin, Gokhan. Systems and methods for detecting metal ion concentrations in subjects. United States: N. p., 2020. Web.
Chang, Christopher J., Long, Jeffrey R., Lee, Sumin, & Barin, Gokhan. Systems and methods for detecting metal ion concentrations in subjects. United States.
Chang, Christopher J., Long, Jeffrey R., Lee, Sumin, and Barin, Gokhan. Tue . "Systems and methods for detecting metal ion concentrations in subjects". United States. https://www.osti.gov/servlets/purl/1637767.
@article{osti_1637767,
title = {Systems and methods for detecting metal ion concentrations in subjects},
author = {Chang, Christopher J. and Long, Jeffrey R. and Lee, Sumin and Barin, Gokhan},
abstractNote = {A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {3}
}

Patent:

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