Systems and methods for relay ionization

Cooks, Robert Graham; Li, Anyin; Hollerbach, Adam

Title: Systems and methods for relay ionization

Abstract

The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.

Inventors:: Cooks, Robert Graham; Li, Anyin; Hollerbach, Adam

Issue Date:: 2020-03-03

Research Org.:: Purdue Univ., West Lafayette, IN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1632639

Patent Number(s):: 10580634

Application Number:: 16/518,291

Assignee:: Purdue Research Foundation (West Lafayette, IN)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

Show more

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/00 - Particle spectrometers or separator tubes
H01J49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks
H01J49/0409 - {Sample holders or containers
H01J49/165 - {Electrospray ionisation}
H01J49/167 - {Capillaries and nozzles specially adapted therefor

Show less

DOE Contract Number:: FG02-06ER15807

Resource Type:: Patent

Resource Relation:: Patent File Date: 07/22/2019

Country of Publication:: United States

Language:: English

Subject:: 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats


                    Cooks, Robert Graham, Li, Anyin, and Hollerbach, Adam. Systems and methods for relay ionization.  United States: N. p., 2020. 
        Web.

Copy to clipboard


                    Cooks, Robert Graham, Li, Anyin, & Hollerbach, Adam. Systems and methods for relay ionization.  United States.

Copy to clipboard


                    Cooks, Robert Graham, Li, Anyin, and Hollerbach, Adam. Tue .  
        "Systems and methods for relay ionization".  United States.  https://www.osti.gov/servlets/purl/1632639.

Copy to clipboard


                    
@article{osti_1632639,

  title        = {Systems and methods for relay ionization},

  author       = {Cooks, Robert Graham and Li, Anyin and Hollerbach, Adam},

  abstractNote = {The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2020},

  month        = {3}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Method and apparatus for electrospray ionization
patent, October 2001

Fenn, John B.
US Patent Document 6,297,499
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6297499

Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph-mass spectrometer-computer analytical system
journal, December 1975

Carroll, D. I.; Dzidic, I.; Stillwell, R. N.
Analytical Chemistry, Vol. 47, Issue 14
https://doi.org/10.1021/ac60364a031

Efficient Separations of Intact Proteins Using Slip-Flow with Nano-Liquid Chromatography–Mass Spectrometry
journal, January 2014

Wu, Zhen; Wei, Bingchuan; Zhang, Ximo
Analytical Chemistry, Vol. 86, Issue 3
https://doi.org/10.1021/ac403233d

Systems and Methods for Analyzing a Sample Using a Mass Spectrometry Probe Configured to Contact the Sample
patent-application, September 2014

Cooks, Robert Graham; Jarmusch, Alan Keith; Kerian, Kevin Scott
US Patent Application 14/209304; 20140264004
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140264004

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer
journal, December 2014

Jjunju, Fred P. M.; Maher, Simon; Li, Anyin
Journal of the American Society for Mass Spectrometry, Vol. 26, Issue 2
https://doi.org/10.1007/s13361-014-1029-2

Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass Spectrometry
journal, January 1995

Kriger, M. Scott.; Cook, Kelsey D.; Ramsey, Roswitha S.
Analytical Chemistry, Vol. 67, Issue 2
https://doi.org/10.1021/ac00098a025

Low temperature plasma probe and methods of use thereof
patent, June 2015

Ouyang, Zheng; Harper, Jason David; Charipar, Nicholas Alan
US Patent Document 9,064,674
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9064674

Inkjet-Printed Microfluidic Multianalyte Chemical Sensing Paper
journal, September 2008

Abe, Koji; Suzuki, Koji; Citterio, Daniel
Analytical Chemistry, Vol. 80, Issue 18, p. 6928-6934
https://doi.org/10.1021/ac800604v

Electrospray ion source. Another variation on the free-jet theme
journal, September 1984

Yamashita, Masamichi; Fenn, John B.
The Journal of Physical Chemistry, Vol. 88, Issue 20
https://doi.org/10.1021/j150664a002

Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals
journal, February 2014

Li, Anyin; Luo, Qingjie; Park, So-Jung
Angewandte Chemie International Edition, Vol. 53, Issue 12, p. 3147-3150
https://doi.org/10.1002/anie.201309193

Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes
journal, September 2014

Mortensen, Daniel N.; Williams, Evan R.
Analytical Chemistry, Vol. 86, Issue 18
https://doi.org/10.1021/ac502545r

Molecular Beams of Macroions. II
journal, May 1970

Mack, L. L.; Kralik, P.; Rheude, A.
The Journal of Chemical Physics, Vol. 52, Issue 10
https://doi.org/10.1063/1.1672733

Handheld Miniature Ion Trap Mass Spectrometers
journal, March 2009

Ouyang, Zheng; Noll, Robert J.; Cooks, R. Graham
Analytical Chemistry, Vol. 81, Issue 7
https://doi.org/10.1021/ac900292w

Desorption electrospray ionization with a portable mass spectrometer: in situ analysis of ambient surfaces
journal, February 2006

Mulligan, Christopher C.; Talaty, Nari; Cooks, R. Graham
Chemical Communications, Issue 16, p. 1709-1711
https://doi.org/10.1039/b517357d

Molecular Beams of Macroions
journal, September 1968

Dole, Malcolm; Mack, L. L.; Hines, R. L.
The Journal of Chemical Physics, Vol. 49, Issue 5
https://doi.org/10.1063/1.1670391

A novel cold plasma jet generated by atmospheric dielectric barrier capillary discharge
journal, May 2006

Zhang, Jialiang; Sun, Jiao; Wang, Dezhen
Thin Solid Films, Vol. 506-507, p. 404-408
https://doi.org/10.1016/j.tsf.2005.08.088

Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry: Microfluidics and Miniaturization
journal, June 2014

Wang, Shujun; Chen, Suming; Wang, Jianing
ELECTROPHORESIS, Vol. 35, Issue 17
https://doi.org/10.1002/elps.201400083

Low Temperature Plasma Probe and Methods of Use Thereof
patent-application, February 2011

Ouyang, Zheng; Harper, Jason; Charipar, Nicholas
US Patent Application 12/863801; 20110042560
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110042560

Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation
journal, January 2006

Chen, Huanwen; Venter, Andre; Cooks, R. Graham
Chemical Communications, Issue 19
https://doi.org/10.1039/b602614a

Ion Transfer Tube for a Mass Spectrometer System
patent-application, June 2012

Wouters, Eloy R.; Makarov, Alexander A.; Atherton, R. Paul
US Patent Application 13/333948; 20120153141
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120153141

Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids
journal, January 2005

Shiea, Jentaie; Huang, Min-Zon; HSu, Hsiu-Jung
Rapid Communications in Mass Spectrometry, Vol. 19, Issue 24, p. 3701-3704
https://doi.org/10.1002/rcm.2243

Miniaturized Source Devices for Optical and Mass Spectrometry
patent-application, September 2005

Karanassios, Vassili
US Patent Application 11/072330; 20050195393
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050195393

Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics
journal, July 2009

Lapainis, Theodore; Rubakhin, Stanislav S.; Sweedler, Jonathan V.
Analytical Chemistry, Vol. 81, Issue 14
https://doi.org/10.1021/ac900936g

Method and apparatus for the mass spectrometric analysis of solutions
patent, July 1985

Labowsky, Michael J.; Fenn, John B.; Yamashita, Masamichi
US Patent Document 4,531,056
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4531056

Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification
journal, December 2008

Mizuno, Hajime; Tsuyama, Naohiro; Harada, Takanori
Journal of Mass Spectrometry, Vol. 43, Issue 12
https://doi.org/10.1002/jms.1460

Process and apparatus for changing the energy of charged particles contained in a gaseous medium
patent, September 1985

Fenn, John B.; Yamashita, Masamichi; Whitehouse, Craig M.
US Patent Document 4,542,293
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4542293

Mass Spectrometry Apparatus
patent-application, November 2013

Kalinitchenko, Iouri
US Patent Application 13/993709; 20130292565
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130292565

Mass Analyzing Apparatus
patent-application, November 2008

Lin, Che-Hsin; Shiea, Jen-Taie; Hsu, Wei-Jen
US Patent Application 11/778666; 20080277579
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080277579

Miniaturization and Geometry Optimization of a Polymer-Based Rectilinear Ion Trap
journal, October 2007

Fico, Miriam; Yu, Meng; Ouyang, Zheng
Analytical Chemistry, Vol. 79, Issue 21
https://doi.org/10.1021/ac0711384

Paper spray ionization of polar analytes using non-polar solvents
journal, January 2011

Li, Anyin; Wang, He; Ouyang, Zheng
Chemical Communications, Vol. 47, Issue 10
https://doi.org/10.1039/c0cc05513a

Current measurements within the electrospray emitter
journal, April 2007

Pozniak, Boguslaw P.; Cole, Richard B.
Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 4
https://doi.org/10.1016/j.jasms.2006.11.012

Shiga-Like Toxin II Derived from Escherichia coli O157:H7 Modifies Renal Handling of Levofloxacin in Rats
journal, May 2002

Zhao, Ying Lan; Cen, Xiao Bo; Ito, Masafumi
Antimicrobial Agents and Chemotherapy, Vol. 46, Issue 5
https://doi.org/10.1128/AAC.46.5.1522-1528.2002

Method and Apparatus for Multiple Electrospray Emitters in Mass Spectrometry
patent-application, June 2011

Kovtoun, Viatcheslav V.; Wouters, Eloy R.; Atherton, R. Paul
US Patent Application 12/642617; 20110147577
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110147577

FLASH: A rapid method for prototyping paper-based microfluidic devices
journal, January 2008

Martinez, Andres W.; Phillips, Scott T.; Wiley, Benjamin J.
Lab on a Chip, Vol. 8, Issue 12, p. 2146-2150
https://doi.org/10.1039/b811135a

Ion generation using wetted porous material
patent, October 2014

Ouyang, Zheng; Wang, He; Manicke, Nicholas E.
US Patent Document 8,859,956
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8859956

Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis
journal, July 2012

Yoon, Sung Hwan; Huang, Yue; Edgar, J. Scott
Analytical Chemistry, Vol. 84, Issue 15
https://doi.org/10.1021/ac300807p

Soft Landing of Complex Molecules on Surfaces
journal, July 2011

Johnson, Grant E.; Hu, Qichi; Laskin, Julia
Annual Review of Analytical Chemistry, Vol. 4, Issue 1, p. 83-104
https://doi.org/10.1146/annurev-anchem-061010-114028

Nucleophilic Addition of Nitrogen to Aryl Cations: Mimicking Titan Chemistry
journal, August 2013

Li, Anyin; Jjunju, Fred P. M.; Cooks, R. Graham
Journal of The American Society for Mass Spectrometry, Vol. 24, Issue 11
https://doi.org/10.1007/s13361-013-0710-1

Profiling pH Gradients Across Nanocapillary Array Membranes Connecting Microfluidic Channels
journal, October 2005

Fa, Keqing; Tulock, Joseph J.; Sweedler, Jonathan V.
Journal of the American Chemical Society, Vol. 127, Issue 40
https://doi.org/10.1021/ja052708p

Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays
journal, February 2007

Martinez, Andres W.; Phillips, Scott T.; Butte, Manish J.
Angewandte Chemie International Edition, Vol. 46, Issue 8, p. 1318-1320
https://doi.org/10.1002/anie.200603817

Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine
journal, March 2000

Karas, M.; Bahr, U.; Dülcks, T.
Fresenius' Journal of Analytical Chemistry, Vol. 366, Issue 6-7, p. 669-676
https://doi.org/10.1007/s002160051561

Direct monitoring of toxic compounds in air using a portable mass spectrometer
journal, February 2006

Mulligan, Christopher C.; Justes, Dina R.; Noll, Robert. J.
The Analyst, Vol. 131, Issue 4, p. 556-567
https://doi.org/10.1039/b517541k

Ionization by Droplet Impact
patent-application, May 2006

Franzen, Jochen
US Patent Application 11/264657; 20060108539
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060108539

Using Laser-Induced Acoustic Desorption/Electrospray Ionization Mass Spectrometry To Characterize Small Organic and Large Biological Compounds in the Solid State and in Solution Under Ambient Conditions
journal, February 2009

Cheng, Sy-Chyi; Cheng, Tain-Lu; Chang, Hui-Chiu
Analytical Chemistry, Vol. 81, Issue 3
https://doi.org/10.1021/ac800896y

Enhanced silver cationization of polycyclic aromatic hydrocarbons containing bay regions in molecular secondary ion mass spectrometry
journal, January 1989

Hand, Owen W.; Winger, Brian E.; Cooks, R. Graham
Biological Mass Spectrometry, Vol. 18, Issue 1
https://doi.org/10.1002/bms.1200180112

Discontinuous atmospheric pressure interface
patent, November 2012

Ouyang, Zheng; Gao, Liang; Cooks, Robert Graham
US Patent Document 8,304,718
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8304718

Computer aided flood control modeling and management system
patent, December 1989

Pate, Gerry E.; Mullinax, Ronald L.; Sutton, Alexander G.
US Patent Document 4,885,706
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4885706

Hand-Held Mass Spectrometer for Environmentally Relevant Analytes Using a Variety of Sampling and Ionization Methods
journal, February 2010

Sanders, Nathaniel L.; Sokol, Ewa; Perry, Richard H.
European Journal of Mass Spectrometry, Vol. 16, Issue 1
https://doi.org/10.1255/ejms.1036

Mass Spectrometry Method, Mass Spectrometer, and Mass Spectrometry System
patent-application, October 2013

Shimada, Haruo; Nakatani, Yoshimasa; Noritake, Yuka
US Patent Application 13/997714; 20130284915
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130284915

New developments in biochemical mass spectrometry: electrospray ionization
journal, May 1990

Smith, Richard D.; Loo, Joseph A.; Edmonds, Charles G.
Analytical Chemistry, Vol. 62, Issue 9
https://doi.org/10.1021/ac00208a002

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry
journal, November 2007

Nemes, Peter; Vertes, Akos
Analytical Chemistry, Vol. 79, Issue 21
https://doi.org/10.1021/ac071181r

Characterization of dielectric barrier electrospray ionization for mass spectrometric detection
journal, May 2010

Stark, Ann Kathrin; Schilling, Michael; Janasek, Dirk
Analytical and Bioanalytical Chemistry, Vol. 397, Issue 5
https://doi.org/10.1007/s00216-010-3749-x

Field induced ion evaporation from liquid surfaces at atmospheric pressure
journal, December 1979

Thomson, B. A.; Iribarne, J. V.
The Journal of Chemical Physics, Vol. 71, Issue 11
https://doi.org/10.1063/1.438198

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
journal, November 2014

Buitrago Santanilla, Alexander; Regalado, Erik L.; Pereira, Tony
Science, Vol. 347, Issue 6217
https://doi.org/10.1126/science.1259203

Enclosed Desorption Electrospray Ionization Probes and Method of Use Thereof
patent-application, August 2015

Cooks, Robert Graham; Ouyang, Zheng; Chen, Chien-Hsun
US Patent Application 14/688496; 20150230738
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20150230738

Combined electrophoretic-separation and electrospray method and system
patent, June 1989

Smith, Richard D.; Olivares, Jose A.
US Patent Document 4,842,701
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4842701

Method and system for desorption electrospray ionization
patent, February 2008

Takats, Zoltan; Gologan, Bogdan; Wiseman, Justin
US Patent Document 7,335,897
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7335897

Miniaturization of Mass Spectrometry Analysis Systems
journal, December 2010

Xu, Wei; Manicke, Nicholas E.; Cooks, Graham R.
JALA: Journal of the Association for Laboratory Automation, Vol. 15, Issue 6
https://doi.org/10.1016/j.jala.2010.06.004

Electrospray Ionization from Nanopipette Emitters with Tip Diameters of Less than 100 nm
journal, August 2013

Yuill, Elizabeth M.; Sa, Niya; Ray, Steven J.
Analytical Chemistry, Vol. 85, Issue 18
https://doi.org/10.1021/ac402214g

Time-of-flight ion-scattering spectrometer for scattering and recoiling for electron density and structure
patent, November 1991

Rabalais, J. Wayne
US Patent Document 5,068,535
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5068535

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter
journal, July 2001

Berkel, Gary J.; Asano, Keiji G.; Schnier, Paul D.
Journal of the American Society for Mass Spectrometry, Vol. 12, Issue 7
https://doi.org/10.1016/S1044-0305(01)00264-1

Miniature Mass Spectrometers
journal, July 2009

Ouyang, Zheng; Cooks, R. Graham
Annual Review of Analytical Chemistry, Vol. 2, Issue 1
https://doi.org/10.1146/annurev-anchem-060908-155229

Handheld Rectilinear Ion Trap Mass Spectrometer
journal, September 2006

Gao, Liang; Song, Qingyu; Patterson, Garth E.
Analytical Chemistry, Vol. 78, Issue 17, p. 5994-6002
https://doi.org/10.1021/ac061144k

Three-dimensional microfluidic devices fabricated in layered paper and tape
journal, December 2008

Martinez, A. W.; Phillips, S. T.; Whitesides, G. M.
Proceedings of the National Academy of Sciences, Vol. 105, Issue 50, p. 19606-19611
https://doi.org/10.1073/pnas.0810903105

In situ analysis of corrosion inhibitors using a portable mass spectrometer with paper spray ionization
journal, January 2013

Jjunju, Fred. P. M.; Li, Anyin; Badu-Tawiah, Abraham
The Analyst, Vol. 138, Issue 13, p. 3740-3748
https://doi.org/10.1039/c3an00249g

Electrospray Ionization Using Wooden Tips
journal, November 2011

Hu, Bin; So, Pui-Kin; Chen, Huanwen
Analytical Chemistry, Vol. 83, Issue 21
https://doi.org/10.1021/ac2017713

Method and system for desorption electrospray ionization
patent-application, October 2005

Takats, Zoltan; Gologan, Bogdan; Wiseman, Justin Michael
US Patent Application 11/090455; 20050230635
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050230635

In situ generation of copper cations and complexation with tebuconazole in a hyphenation of electrochemistry with mass spectrometry
journal, March 2013

Jaklová Dytrtová, Jana; Jakl, Michal; Schröder, Detlef
International Journal of Mass Spectrometry, Vol. 338
https://doi.org/10.1016/j.ijms.2013.01.005

Microfabricated electrospray emitter arrays with integrated extractor and accelerator electrodes for the propulsion of small spacecraft
journal, June 2014

Dandavino, S.; Ataman, C.; Ryan, C. N.
Journal of Micromechanics and Microengineering, Vol. 24, Issue 7
https://doi.org/10.1088/0960-1317/24/7/075011

Efficiency of nano-electrospray ionization
journal, October 2005

El-Faramawy, Ayman; Siu, K. W. Michael; Thomson, Bruce A.
Journal of the American Society for Mass Spectrometry, Vol. 16, Issue 10
https://doi.org/10.1016/j.jasms.2005.06.011

On the evaporation of small ions from charged droplets
journal, January 1976

Iribarne, J. V.
The Journal of Chemical Physics, Vol. 64, Issue 6
https://doi.org/10.1063/1.432536

Ion spray apparatus and method
patent, August 1989

Henion, John D.; Covey, Thomas R.; Bruins, Andries P.
US Patent Document 4,861,988
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4861988

The Electrical Discharge from Liquid Points, and a Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces
journal, February 1914

Zeleny, John
Physical Review, Vol. 3, Issue 2
https://doi.org/10.1103/PhysRev.3.69

Monitoring of Reaction Intermediates in the Gas Phase: Ruthenium-Catalyzed C–C Coupling
journal, November 2014

Škríba, Anton; Schulz, Jiří; Roithová, Jana
Organometallics, Vol. 33, Issue 23
https://doi.org/10.1021/om500933w

Enhancement of the performance of organic solar cells by electrospray deposition with optimal solvent system
journal, February 2014

Zhao, Xin-Yan; Wang, Xizu; Lim, Siew Lay
Solar Energy Materials and Solar Cells, Vol. 121
https://doi.org/10.1016/j.solmat.2013.10.020

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry
journal, January 2010

Wang, He; Liu, Jiangjiang; Cooks, R. Graham
Angewandte Chemie, Vol. 122, Issue 5, p. 889-892
https://doi.org/10.1002/ange.200906314

Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989

Fenn, J.; Mann, M.; Meng, C.
Science, Vol. 246, Issue 4926, p. 64-71
https://doi.org/10.1126/science.2675315

Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy
journal, September 2014

Li, Anyin; Baird, Zane; Bag, Soumabha
Angewandte Chemie International Edition
https://doi.org/10.1002/anie.201406660

Low-Cost Printing of Poly(dimethylsiloxane) Barriers To Define Microchannels in Paper
journal, May 2008

Bruzewicz, Derek A.; Reches, Meital; Whitesides, George M.
Analytical Chemistry, Vol. 80, Issue 9, p. 3387-3392
https://doi.org/10.1021/ac702605a

Microfluidic capture and release of bacteria in a conical nanopore array
journal, January 2012

Guo, Peng; Hall, Eric W.; Schirhagl, Romana
Lab Chip, Vol. 12, Issue 3
https://doi.org/10.1039/C2LC21092D

Analysis of Hydrocarbon Liquid and Solid Samples
patent-application, June 2014

Wu, Chunping; Walters, Clifford C.; Qian, Kuangnan
US Patent Document 14/071712; 20140165701
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140165701

Arc-Free Atmospheric Pressure Cold Plasma Jets: A Review
journal, November 2007

Laroussi, Mounir; Akan, Tamer
Plasma Processes and Polymers, Vol. 4, Issue 9
https://doi.org/10.1002/ppap.200700066

Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations
journal, August 2012

Badu-Tawiah, Abraham K.; Li, Anyin; Jjunju, Fred P. M.
Angewandte Chemie, Vol. 124, Issue 37, p. 9551-9555
https://doi.org/10.1002/ange.201205044

Enhanced detection of olefins using ambient ionization mass spectrometry: Ag+ adducts of biologically relevant alkenes
journal, November 2010

Jackson, Ayanna U.; Shum, Thomas; Sokol, Ewa
Analytical and Bioanalytical Chemistry, Vol. 399, Issue 1
https://doi.org/10.1007/s00216-010-4349-5

Enclosed desorption electrospray ionization
patent-application, July 2008

Venter, Andre; Cooks, Robert
US Patent Application 12/005593; 20080156985
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080156985

Direct analysis of 4-methylimidazole in foods using paper spray mass spectrometry
journal, January 2013

Li, Anyin; Wei, Pu; Hsu, Hsu-Chen
The Analyst, Vol. 138, Issue 16
https://doi.org/10.1039/c3an00888f

CD14 expression by human mononuclear phagocytes is modulated by Clostridium difficile toxin B
journal, December 1999

Siffert, Jean-Claude; Müller, Christian D.; Dumont, Serge
Microbes and Infection, Vol. 1, Issue 14
https://doi.org/10.1016/S1286-4579(99)00247-6

Paper-Based Microfluidic Devices by Plasma Treatment
journal, December 2008

Li, Xu; Tian, Junfei; Nguyen, Thanh
Analytical Chemistry, Vol. 80, Issue 23, p. 9131-9134
https://doi.org/10.1021/ac801729t

Affecting Protein Charge State Distributions in Nano-Electrospray Ionization via In-Spray Solution Mixing Using Theta Capillaries
journal, April 2014

Fisher, Christine M.; Kharlamova, Anastasia; McLuckey, Scott A.
Analytical Chemistry, Vol. 86, Issue 9
https://doi.org/10.1021/ac500721r

Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics
journal, February 2014

Lafrenière, Nelson M.; Shih, Steve CC; Abu-Rabie, Paul
Bioanalysis, Vol. 6, Issue 3
https://doi.org/10.4155/bio.13.311

Similar Records in DOE Patents and OSTI.GOV collections:

Systems and methods for relay ionization

Patent Cooks, Robert Graham; Li, Anyin; Hollerbach, Adam

The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.
Full Text Available
Systems and methods for relay ionization

Patent Cooks, Robert Graham; Li, Anyin; Hollerbach, Adam

The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.
Full Text Available
Device and system for selective ionization and analyte detection and method of using the same

Patent Ewing, Robert G.; Valenzuela, Blandina R.; Freeburg, Eric

Disclosed herein are embodiments of a system for selectively ionizing samples that may comprise a plurality of different analytes that are not normally detectable using the same ionization technique. The disclosed system comprises a unique split flow tube that can be coupled with a plurality of ionization sources to facilitate using different ionization techniques for the same sample. Also disclosed herein are embodiments of a method for determining the presence of analytes in a sample, wherein the number and type of detectable analytes that can be identified is increased and sensitivity and selectivity are not sacrificed.
Full Text Available
Systems and methods for cylindrical hall thrusters with independently controllable ionization and acceleration stages

Patent Diamant, Kevin David; Raitses, Yevgeny; Fisch, Nathaniel Joseph

Systems and methods may be provided for cylindrical Hall thrusters with independently controllable ionization and acceleration stages. The systems and methods may include a cylindrical channel having a center axial direction, a gas inlet for directing ionizable gas to an ionization section of the cylindrical channel, an ionization device that ionizes at least a portion of the ionizable gas within the ionization section to generate ionized gas, and an acceleration device distinct from the ionization device. The acceleration device may provide an axial electric field for an acceleration section of the cylindrical channel to accelerate the ionized gas through themore » « less
Full Text Available
Device and system for selective ionization and analyte detection and method of using the same

Patent Denis, Elizabeth; Dockendorff, Brian; Ewing, Robert G.; ...

Disclosed herein are embodiments of a system for selectively ionizing samples that may comprise a plurality of different analytes that are not normally detectable using the same ionization technique. The disclosed system comprises a unique split flow tube that can be coupled with a plurality of ionization sources to facilitate using different ionization techniques for the same sample. Also disclosed herein are embodiments of a method for determining the presence of analytes in a sample, wherein the number and type of detectable analytes that can be identified is increased and sensitivity and selectivity are not sacrificed.
Full Text Available

Similar Records

Title: Systems and methods for relay ionization

Abstract

Citation Formats

Method and apparatus for electrospray ionization patent, October 2001

Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph-mass spectrometer-computer analytical system journal, December 1975

Efficient Separations of Intact Proteins Using Slip-Flow with Nano-Liquid Chromatography–Mass Spectrometry journal, January 2014

Systems and Methods for Analyzing a Sample Using a Mass Spectrometry Probe Configured to Contact the Sample patent-application, September 2014

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer journal, December 2014

Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass Spectrometry journal, January 1995

Low temperature plasma probe and methods of use thereof patent, June 2015

Inkjet-Printed Microfluidic Multianalyte Chemical Sensing Paper journal, September 2008

Electrospray ion source. Another variation on the free-jet theme journal, September 1984

Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals journal, February 2014

Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes journal, September 2014

Molecular Beams of Macroions. II journal, May 1970

Handheld Miniature Ion Trap Mass Spectrometers journal, March 2009

Desorption electrospray ionization with a portable mass spectrometer: in situ analysis of ambient surfaces journal, February 2006

Molecular Beams of Macroions journal, September 1968

A novel cold plasma jet generated by atmospheric dielectric barrier capillary discharge journal, May 2006

Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry: Microfluidics and Miniaturization journal, June 2014

Low Temperature Plasma Probe and Methods of Use Thereof patent-application, February 2011

Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation journal, January 2006

Ion Transfer Tube for a Mass Spectrometer System patent-application, June 2012

Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids journal, January 2005

Miniaturized Source Devices for Optical and Mass Spectrometry patent-application, September 2005

Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics journal, July 2009

Method and apparatus for the mass spectrometric analysis of solutions patent, July 1985

Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification journal, December 2008

Process and apparatus for changing the energy of charged particles contained in a gaseous medium patent, September 1985

Mass Spectrometry Apparatus patent-application, November 2013

Mass Analyzing Apparatus patent-application, November 2008

Miniaturization and Geometry Optimization of a Polymer-Based Rectilinear Ion Trap journal, October 2007

Paper spray ionization of polar analytes using non-polar solvents journal, January 2011

Current measurements within the electrospray emitter journal, April 2007

Shiga-Like Toxin II Derived from Escherichia coli O157:H7 Modifies Renal Handling of Levofloxacin in Rats journal, May 2002

Method and Apparatus for Multiple Electrospray Emitters in Mass Spectrometry patent-application, June 2011

FLASH: A rapid method for prototyping paper-based microfluidic devices journal, January 2008

Ion generation using wetted porous material patent, October 2014

Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis journal, July 2012

Soft Landing of Complex Molecules on Surfaces journal, July 2011

Nucleophilic Addition of Nitrogen to Aryl Cations: Mimicking Titan Chemistry journal, August 2013

Profiling pH Gradients Across Nanocapillary Array Membranes Connecting Microfluidic Channels journal, October 2005

Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays journal, February 2007

Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine journal, March 2000

Direct monitoring of toxic compounds in air using a portable mass spectrometer journal, February 2006

Ionization by Droplet Impact patent-application, May 2006

Using Laser-Induced Acoustic Desorption/Electrospray Ionization Mass Spectrometry To Characterize Small Organic and Large Biological Compounds in the Solid State and in Solution Under Ambient Conditions journal, February 2009

Enhanced silver cationization of polycyclic aromatic hydrocarbons containing bay regions in molecular secondary ion mass spectrometry journal, January 1989

Discontinuous atmospheric pressure interface patent, November 2012

Computer aided flood control modeling and management system patent, December 1989

Hand-Held Mass Spectrometer for Environmentally Relevant Analytes Using a Variety of Sampling and Ionization Methods journal, February 2010

Mass Spectrometry Method, Mass Spectrometer, and Mass Spectrometry System patent-application, October 2013

New developments in biochemical mass spectrometry: electrospray ionization journal, May 1990

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry journal, November 2007

Characterization of dielectric barrier electrospray ionization for mass spectrometric detection journal, May 2010

Field induced ion evaporation from liquid surfaces at atmospheric pressure journal, December 1979

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules journal, November 2014

Enclosed Desorption Electrospray Ionization Probes and Method of Use Thereof patent-application, August 2015

Combined electrophoretic-separation and electrospray method and system patent, June 1989

Method and system for desorption electrospray ionization patent, February 2008

Miniaturization of Mass Spectrometry Analysis Systems journal, December 2010

Electrospray Ionization from Nanopipette Emitters with Tip Diameters of Less than 100 nm journal, August 2013

Time-of-flight ion-scattering spectrometer for scattering and recoiling for electron density and structure patent, November 1991

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter journal, July 2001

Miniature Mass Spectrometers journal, July 2009

Handheld Rectilinear Ion Trap Mass Spectrometer journal, September 2006

Three-dimensional microfluidic devices fabricated in layered paper and tape journal, December 2008

In situ analysis of corrosion inhibitors using a portable mass spectrometer with paper spray ionization journal, January 2013

Electrospray Ionization Using Wooden Tips journal, November 2011

Method and system for desorption electrospray ionization patent-application, October 2005

In situ generation of copper cations and complexation with tebuconazole in a hyphenation of electrochemistry with mass spectrometry journal, March 2013

Microfabricated electrospray emitter arrays with integrated extractor and accelerator electrodes for the propulsion of small spacecraft journal, June 2014

Efficiency of nano-electrospray ionization journal, October 2005

On the evaporation of small ions from charged droplets journal, January 1976

Ion spray apparatus and method patent, August 1989

The Electrical Discharge from Liquid Points, and a Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces journal, February 1914

Monitoring of Reaction Intermediates in the Gas Phase: Ruthenium-Catalyzed C–C Coupling journal, November 2014

Enhancement of the performance of organic solar cells by electrospray deposition with optimal solvent system journal, February 2014

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry journal, January 2010

Electrospray ionization for mass spectrometry of large biomolecules journal, October 1989

Method and apparatus for electrospray ionization
patent, October 2001

Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph-mass spectrometer-computer analytical system
journal, December 1975

Efficient Separations of Intact Proteins Using Slip-Flow with Nano-Liquid Chromatography–Mass Spectrometry
journal, January 2014

Systems and Methods for Analyzing a Sample Using a Mass Spectrometry Probe Configured to Contact the Sample
patent-application, September 2014

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer
journal, December 2014

Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass Spectrometry
journal, January 1995

Low temperature plasma probe and methods of use thereof
patent, June 2015

Inkjet-Printed Microfluidic Multianalyte Chemical Sensing Paper
journal, September 2008

Electrospray ion source. Another variation on the free-jet theme
journal, September 1984

Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals
journal, February 2014

Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes
journal, September 2014

Molecular Beams of Macroions. II
journal, May 1970

Handheld Miniature Ion Trap Mass Spectrometers
journal, March 2009

Desorption electrospray ionization with a portable mass spectrometer: in situ analysis of ambient surfaces
journal, February 2006

Molecular Beams of Macroions
journal, September 1968

A novel cold plasma jet generated by atmospheric dielectric barrier capillary discharge
journal, May 2006

Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry: Microfluidics and Miniaturization
journal, June 2014

Low Temperature Plasma Probe and Methods of Use Thereof
patent-application, February 2011

Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation
journal, January 2006

Ion Transfer Tube for a Mass Spectrometer System
patent-application, June 2012

Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids
journal, January 2005

Miniaturized Source Devices for Optical and Mass Spectrometry
patent-application, September 2005

Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics
journal, July 2009

Method and apparatus for the mass spectrometric analysis of solutions
patent, July 1985

Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification
journal, December 2008

Process and apparatus for changing the energy of charged particles contained in a gaseous medium
patent, September 1985

Mass Spectrometry Apparatus
patent-application, November 2013

Mass Analyzing Apparatus
patent-application, November 2008

Miniaturization and Geometry Optimization of a Polymer-Based Rectilinear Ion Trap
journal, October 2007

Paper spray ionization of polar analytes using non-polar solvents
journal, January 2011

Current measurements within the electrospray emitter
journal, April 2007

Shiga-Like Toxin II Derived from Escherichia coli O157:H7 Modifies Renal Handling of Levofloxacin in Rats
journal, May 2002

Method and Apparatus for Multiple Electrospray Emitters in Mass Spectrometry
patent-application, June 2011

FLASH: A rapid method for prototyping paper-based microfluidic devices
journal, January 2008

Ion generation using wetted porous material
patent, October 2014

Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis
journal, July 2012

Soft Landing of Complex Molecules on Surfaces
journal, July 2011

Nucleophilic Addition of Nitrogen to Aryl Cations: Mimicking Titan Chemistry
journal, August 2013

Profiling pH Gradients Across Nanocapillary Array Membranes Connecting Microfluidic Channels
journal, October 2005

Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays
journal, February 2007

Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine
journal, March 2000

Direct monitoring of toxic compounds in air using a portable mass spectrometer
journal, February 2006

Ionization by Droplet Impact
patent-application, May 2006

Using Laser-Induced Acoustic Desorption/Electrospray Ionization Mass Spectrometry To Characterize Small Organic and Large Biological Compounds in the Solid State and in Solution Under Ambient Conditions
journal, February 2009

Enhanced silver cationization of polycyclic aromatic hydrocarbons containing bay regions in molecular secondary ion mass spectrometry
journal, January 1989

Discontinuous atmospheric pressure interface
patent, November 2012

Computer aided flood control modeling and management system
patent, December 1989

Hand-Held Mass Spectrometer for Environmentally Relevant Analytes Using a Variety of Sampling and Ionization Methods
journal, February 2010

Mass Spectrometry Method, Mass Spectrometer, and Mass Spectrometry System
patent-application, October 2013

New developments in biochemical mass spectrometry: electrospray ionization
journal, May 1990

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry
journal, November 2007

Characterization of dielectric barrier electrospray ionization for mass spectrometric detection
journal, May 2010

Field induced ion evaporation from liquid surfaces at atmospheric pressure
journal, December 1979

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
journal, November 2014

Enclosed Desorption Electrospray Ionization Probes and Method of Use Thereof
patent-application, August 2015

Combined electrophoretic-separation and electrospray method and system
patent, June 1989

Method and system for desorption electrospray ionization
patent, February 2008

Miniaturization of Mass Spectrometry Analysis Systems
journal, December 2010

Electrospray Ionization from Nanopipette Emitters with Tip Diameters of Less than 100 nm
journal, August 2013

Time-of-flight ion-scattering spectrometer for scattering and recoiling for electron density and structure
patent, November 1991

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter
journal, July 2001

Miniature Mass Spectrometers
journal, July 2009

Handheld Rectilinear Ion Trap Mass Spectrometer
journal, September 2006

Three-dimensional microfluidic devices fabricated in layered paper and tape
journal, December 2008

In situ analysis of corrosion inhibitors using a portable mass spectrometer with paper spray ionization
journal, January 2013

Electrospray Ionization Using Wooden Tips
journal, November 2011

Method and system for desorption electrospray ionization
patent-application, October 2005

In situ generation of copper cations and complexation with tebuconazole in a hyphenation of electrochemistry with mass spectrometry
journal, March 2013

Microfabricated electrospray emitter arrays with integrated extractor and accelerator electrodes for the propulsion of small spacecraft
journal, June 2014

Efficiency of nano-electrospray ionization
journal, October 2005

On the evaporation of small ions from charged droplets
journal, January 1976

Ion spray apparatus and method
patent, August 1989

The Electrical Discharge from Liquid Points, and a Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces
journal, February 1914

Monitoring of Reaction Intermediates in the Gas Phase: Ruthenium-Catalyzed C–C Coupling
journal, November 2014

Enhancement of the performance of organic solar cells by electrospray deposition with optimal solvent system
journal, February 2014

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry
journal, January 2010

Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989

Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy
journal, September 2014

Low-Cost Printing of Poly(dimethylsiloxane) Barriers To Define Microchannels in Paper
journal, May 2008

Microfluidic capture and release of bacteria in a conical nanopore array
journal, January 2012