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Title: Systems and methods for determining flux distribution

Abstract

Provided are systems and methods for accurately determining flux distribution in organisms or cells without use of metabolic flux analysis data. The methods include estimating flux distributions in multiple reference strains (variants of a parental strain) using experimentally determined extracellular flux data from the reference strains, and determining a flux distribution for the parental strain from the estimated flux distributions for the reference strains and from experimentally measured extracellular fluxes for the parental strain. The systems are configured for carrying out the methods.

Inventors:
;
Issue Date:
Research Org.:
Wisconsin Alumni Research Foundation, Madison, WI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1632619
Patent Number(s):
10573404
Application Number:
15/015,561
Assignee:
Wisconsin Alumni Research Foundation (Madison, WI)
Patent Classifications (CPCs):
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16B - BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
DOE Contract Number:  
SC0008103
Resource Type:
Patent
Resource Relation:
Patent File Date: 02/04/2016
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Reed, Jennifer Leanne, and Long, Matthew Ray. Systems and methods for determining flux distribution. United States: N. p., 2020. Web.
Reed, Jennifer Leanne, & Long, Matthew Ray. Systems and methods for determining flux distribution. United States.
Reed, Jennifer Leanne, and Long, Matthew Ray. Tue . "Systems and methods for determining flux distribution". United States. https://www.osti.gov/servlets/purl/1632619.
@article{osti_1632619,
title = {Systems and methods for determining flux distribution},
author = {Reed, Jennifer Leanne and Long, Matthew Ray},
abstractNote = {Provided are systems and methods for accurately determining flux distribution in organisms or cells without use of metabolic flux analysis data. The methods include estimating flux distributions in multiple reference strains (variants of a parental strain) using experimentally determined extracellular flux data from the reference strains, and determining a flux distribution for the parental strain from the estimated flux distributions for the reference strains and from experimentally measured extracellular fluxes for the parental strain. The systems are configured for carrying out the methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {2}
}

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